In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction. We characterized the role of integrin α6β4/HD and caskin2 in force generation... Show moreIn this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction. We characterized the role of integrin α6β4/HD and caskin2 in force generation via FA, investigated the underlying crosstalk between adhesions and cytoskeletons. Moreover, we also explored the mechanism that drives the integrin αVβ5 clustering in FCLs, in which cell tension is also involved. Last but not the least, we investigated the role of an unexplored protein, caskin2, in the regulation of cellular mechanics. Show less
