Pancreatic islet transplantation by a new method is introduced here : the isolation of islets in an organ preservation solution, the University of Wisconsin solution. A new concept allowing for the... Show morePancreatic islet transplantation by a new method is introduced here : the isolation of islets in an organ preservation solution, the University of Wisconsin solution. A new concept allowing for the first time large-scale isolation and transplantation of consistently near 100% pure islets of Langerhans in a preclinical dog model with fasting normoglycemia up to 3 years posttransplant. Detailed metabolic studies demonstrated normal insulin levels after meals with preservation of gut hormone action stimulating insulin secretion at the mild hyperglycemia after meals. The introduction of the University of Wisconsin solution organ preservation solution for islet isolation at the start of these studies in 1989 is a new concept … and has been shown by now in 2022 , world-wide , to make the future of islet isolation and transplantation methods for insulin-dependent diabetes mellitus (IDDM). Show less
Oesophagostomum spp. are common nematode parasites of sheep, goats, cattle, and also of monkeys. Infection with this parasite can cause serious gastro-intestinal symptoms, which may lead to death.... Show moreOesophagostomum spp. are common nematode parasites of sheep, goats, cattle, and also of monkeys. Infection with this parasite can cause serious gastro-intestinal symptoms, which may lead to death. Since the beginning of this century, the parasite has also been described in humans on several occasions. Human infection with Oesophagostomum has always been considered as a zoonosis, an accidental infection of man with an animal parasite. It was assumed that its life-cycle was not completed in this unsuitable host. Show less
Deze studie beschrijft een politiek-historisch proces en vormt een bijdrage aan de systematische studie van internationale territoriale conflicten vanuit het gezichtspunt van de politieke... Show moreDeze studie beschrijft een politiek-historisch proces en vormt een bijdrage aan de systematische studie van internationale territoriale conflicten vanuit het gezichtspunt van de politieke geografie. Tevens worden aspecten van het Europese imperialisme van de late 19e eeuw nader verklaard. De conflicten tussen Frankrijk en de Association Internationale du Congo (AIC) en tussen Portugal en de AIC over de opdeling van Centraal-Afrika, een proces dat plaatsvond in de periode 1875-1885, dienen als voorbeelden. Het boek bestaat uit drie delen. In deel 1 komen de theoretische en methodologische aspecten aan de orde. Deel 2 bestaat uit de case-study. Hoofdstuk 3 behelst de beleidsbepaling. De hoofdstukken 4, 5 en 6 behandelen de beleidsuitvoering van de factoren die rechtstreeks bij de territoriale conflicten betrokken waren: Leopold II, Frankrijk en Portugal. In hoofdstuk 7 staat de conflictoplossing centraal. Deel 3 bestaat uit ‚‚n hoofdstuk. Eerst wordt nagegaan in hoeverre de theorie‰n van toepassing zijn op dit onderdeel van de opdeling van Afrika. De conclusie is dat ze meer zeggen over de afloop van dit stukje opdelingsgeschiedenis dan over het ontstaan ervan. Die afloop betreft het gehele proces van de opdeling van Centraal-Afrika, en wordt geanalyseerd met behulp van de begrippen en modellen uit hoofdstuk 2. Show less
Pawn or pioneer, Rotterdam - municipal activity in the 19th century. The liberal watchword 'laissez-faire' gives succinct sum and substance to the preference that nineteenth century liberal... Show morePawn or pioneer, Rotterdam - municipal activity in the 19th century. The liberal watchword 'laissez-faire' gives succinct sum and substance to the preference that nineteenth century liberal administrators had for state restraint. Society was well served, they believed, when government took a modest role and only in specific cases intervened in the public domain. The defence of the country against hostile forces and against the sea were considered to be government__s responsibility. The maintenance of public order and the building of public roads by the government also enjoyed liberal approval. But there it really ended. Anything else was better left to the untrammelled dynamics of social forces. The machinery of government however grew vigorously under liberal hegemony in the nineteenth century. The historian Jan van den Noort has carried out an inquiry into the causes and reasons for that growth. He focuses his attention on the growth of municipal activity and tries to explain this. In doing so he concentrates on the foundation of municipal utilities in Rotterdam. In only a few decades the municipal utilities for water, gas and electricity, municipal sanitation and harbour operations emerged there.|De liberale leuze 'laissez-faire' is een bondige samenvatting van de voorkeur die negentiende-eeuwse liberale bestuurders hadden voor staatsonthouding. De samenleving was ermee gediend, meenden zij, als de overheid zich zo bescheiden mogelijk opstelde en slechts in enkele gevallen ingreep in het maatschappelijk proces. De verdediging van het land tegen vijandelijke legers en de strijd tegen de zee werden tot de overheidstaak gerekend. De handhaving van de openbare orde en de aanleg van openbare wegen door de overheid hadden eveneens liberale instemming. Maar daarmee was het wel zo'n beetje gezegd. De rest kon nog het beste worden overgelaten aan het vrije spel van maatschappelijke krachten. Onder liberale hegemonie groeide het overheidsapparaat in de negentiende eeuw evenwel sterk. De historicus Jan van den Noort deed onderzoek naar de oorzaken en motieven voor die groei. Hij richtte zijn aandacht op de groei van gemeentelijke activiteit en probeerde deze te verklaren. Daarbij concentreerde hij zich op de stichting van gemeentebedrijven te Rotterdam. In enkele decennia slechts ontstonden daar de gemeentebedrijven voor water, gas en elektriciteit, gemeentereiniging en havenexploitatie. Show less
The thesis describes infrared radiation and dust properties of the Magellanic Clouds, together with comparisons with emission at other wavelength regimes. Observations of the SMC and LMC were made... Show moreThe thesis describes infrared radiation and dust properties of the Magellanic Clouds, together with comparisons with emission at other wavelength regimes. Observations of the SMC and LMC were made with the IRAS satellite. Maps are presented at wavelengths of 12, 25, 60 and 100 _m. From these maps a list of discrete infrared sources is extracted. This source list is compared to known object lists (foreground stars, SMC stars, H_ nebulosities, clusters, supernova remnants, planetary nebula and dark clouds). There is a good correlation between HII regions and infrared emission from the SMC. For the LMC a similar presentation and discussion is given as for the SMC. A list of discrete sources is extracted, which is compared to similar source lists. As for the SMC, there is also a very good correlation of the infrared emission peaks with HII regions in the LMC. The Galactic infrared foreground emission is discussed. Foreground filaments disturb the image of this Cloud, and the IRAS data show significant variations in the foreground. The relation between the infrared foreground emission and the atomic hydrogen content is found to be non-linear. An estimate for the foreground infrared emission is derived, based on the average gas-to-dust ratio. The foreground towards the LMC varies from 0.07 to 0.17 magnitude, with an average of 0.10. A more or less constant foreground of 0.08 magnitude towards the SMC is found. Global properties of the Magellanic Clouds are discussed. Integrated infrared flux densities, infrared sizes, infrared luminosities and dust temperatures are derived. The infrared morphology is discussed, together with the temperature distribution. It turns out that the Greater 30 Doradus Region emits about 40 % of all infrared radiation. The density of the interstellar radiation field in the Clouds is derived. On average the fields are 7 times stronger than the Solar Neighbourhood field. A relation is found between infrared emission and the H_ supergiant shells in the LMC. Comparisons of the infrared maps are presented with ultraviolet data, H_ maps and with radio continuum observations. The SMC is 10 to 20 times weaker than the LMC in the infrared. The thesis describes dust properties in the Magellanic Clouds. The mid-infrared (12 and 25 _m) emission in the Clouds is less than that in the Local Group spiral galaxies. It is most likely that very small grains are responsible for this emission. Dust masses are derived for the combined warm (~50 K) and cool (25 K) dust components. The mass present in the cold (15 K) dust component is estimated to be between 1/3 and 1 times the mass of cool dust. Total dust masses of 550000 solar masses for the LMC and 24000 solar masses for the SMC are derived. Dust column density maps are presented for both Clouds. From a comparison of the infrared maps with atomic hydrogen maps, similar non-linear relations are found as for the Galactic foreground. Global properties of the Clouds are discussed in relation with irregular galaxies and in relation with Local Group spiral galaxies. The infrared colours of the Clouds are similar to the colours of other irregular galaxies. There are some exceptions, NGC 6822 and NGC 1569 have much lower f12 _m/f25 _m ratios than the Clouds, but their f60 _m/f100 _m ratios are similar. The luminosity-to-mass ratio of the SMC is similar to that of other irregular galaxies. That ratio of the LMC is an order of magnitude higher, and is comparable to that of spiral galaxies such as IC 342, M101and M33. Relative to the irregular galaxies, the gas-to-dust ratio in the LMC is low. The LMC gas-to-dust ratio is probably not very different from that in M31 and M33. For the LMC a ratio 3 times higher than for the Milky Way is found; for the SMC the ratio is 50 times higher than for the Milky Way. The LMC value agrees well with that of other authors, based on photometric B and V measurements and Ly_ absorption. The SMC value is, however, 3 to 6 times higher than those ratios. This difference is explained by Galactic foreground difficulties in photometric observations: high foreground extinction values from Chapter IV suggest large variations on small scales for individual stars. A new fit is made to the EB-V and NHI data, showing agreement with the dust mass based on infrared data. These findings also agree with the integrated ratio L100 _m/MHI, which is about 30 times lower for the SMC than for the Galaxy. Show less
This study focuses on the factors which determine the size of the breeding population of rabbits, at the end of the winter. The main questions were: What determines the size of the breeding... Show moreThis study focuses on the factors which determine the size of the breeding population of rabbits, at the end of the winter. The main questions were: What determines the size of the breeding population? Do rabbit numbers increase to carrying capacity set by the food, or are they kept below this limit by e.g. intrinsic responses to density or by predation? Show less
