This thesis summarizes a PhD research project, in which we successfully developed and tested a smartphone-based version of the AAT. We used the mobile AAT to show that approach-avoidance tendencies... Show moreThis thesis summarizes a PhD research project, in which we successfully developed and tested a smartphone-based version of the AAT. We used the mobile AAT to show that approach-avoidance tendencies can undergo substantial state-like changes. We further demonstrate how these changes can be systematically related to other state-variables and how important health-related outcomes such as overweight and obesity, can be explained by disruptions of these dynamics. Our findings have broad implications for approach-avoidance research and task-based research in general, as they reveal how smartphones can be used to get insights into the dynamic nature of task outcomes and how (disruptions of) these dynamics can have important real-life consequences. Show less
Two types of financial incentives can help improve healthy lifestyles: carrots (a reward where one can gain something) and sticks (a deposit contract where one can lose something). In a deposit... Show moreTwo types of financial incentives can help improve healthy lifestyles: carrots (a reward where one can gain something) and sticks (a deposit contract where one can lose something). In a deposit contract, participants deposit own money and can lose or earn it back depending on lifestyle changes. We studied the potential of deposit contracts to stimulate a healthy lifestyle.A smartphone app was developed together with the Swiss university ETH Zurich to conduct experimental research into the effects of deposit contracts. In addition, we collaborated with the American company WayBetter to observe the effects of commercially available deposit contracts. Finally, the opinion of people with cardiovascular disease and healthcare professionals regarding financial incentives and deposit contracts for lifestyle change was investigated.The results show that deposit contracts can have strong effects on exercise behavior (daily step counts) in the short term. The results also show that voluntary participation in deposit contracts is limited, but can be increased by doubling the amount deposited and by allowing participants to determine the amount themselves. Finally, healthcare providers think it is a good idea to use financial incentives, but people with cardiovascular disease themselves are skeptical about the use of deposit contracts. Show less
Differentiation has evolved into a systematic feature of European integration. Still, EU member states have been eager to maintain unity and not let differentiated integration (DI) be reflected in... Show moreDifferentiation has evolved into a systematic feature of European integration. Still, EU member states have been eager to maintain unity and not let differentiated integration (DI) be reflected in institutions and processes of EU governance. The sovereign debt crisis was a turning point, triggering an unprecedented reinforcement of euro area specific institutions and policies. So far, few contributions have studied the institutional implications of DI in the EU. This dissertation examines whether and, if so, how and with what implications DI has been institutionalised in EMU governance. It analyses the organisational inclusiveness of crisis management structures, the evolution of the Eurogroup and Eurogroup Working Group, procedural norms and elite ideas. The findings suggest that the distinction between euro area insiders and outsiders has become embedded in how member state representatives perceive political reality, determine mutual role expectations and organise governance processes. While this institutionalisation of DI in EMU was facilitated by particular circumstances of the sovereign debt crisis, its implications are evident in EMU governance and reform processes until today. The dissertation makes theoretical and empirical contributions to account for DI in institutional and political developments in EMU and, thus, aims to enrich institutionalist debates in EU studies. Show less
This dissertation focuses on identifying neural mechanisms underlying social evaluations and self-views from a parent-adolescent perspective among adolescents with and without depression, and their... Show moreThis dissertation focuses on identifying neural mechanisms underlying social evaluations and self-views from a parent-adolescent perspective among adolescents with and without depression, and their parents. As part of RE-PAIR, affective and neural responses to praise and criticism about the adolescent child, and neural responses to reliving positive autobiographical memories were assessed, using ecologically valid fMRI-tasks. Particularly criticism seems to be highly salient to parents and adolescents, activating the salience network and decreasing mood. Both praise and reliving positive autobiographical memories activate areas important for self-referential processing in adolescents, which might reflect the ‘positive self’. Aberrant self-related processing when reliving autobiographical memories and increased sensitivity to parental criticism might be key underlying neural mechanisms in adolescent depression. By feeling more negatively, having more negative self-views, interpreting the environment as more negatively, memorizing past experiences in a more negative way, and focusing on negative events more often, adolescents with depression seem to have multiple negativity biases. These negativity biases are likely to negatively impact social relationships, potentially further reinforcing negative feelings and a negative self. Interventions exploring and strengthening the positive self, in particular the positive self aligning with the current self, might be useful for treating, or even preventing adolescent depression. Show less
About 1 in 650-1000 children are born with a 47,XXY, 47,XXX or 47,XYY chromosomal pattern (i.e, sex chromosome trisomies, SCT). The presence of SCT is associated with an increased risk for... Show moreAbout 1 in 650-1000 children are born with a 47,XXY, 47,XXX or 47,XYY chromosomal pattern (i.e, sex chromosome trisomies, SCT). The presence of SCT is associated with an increased risk for neurodevelopmental difficulties across the life-span. Studying neurodevelopment in early childhood in children with SCT could signal deviations in development that serve as risk markers to guide clinical care. This thesis explored the development of self-regulation (emotion, cognition, and behavior) in SCT children and population-based controls, aged 1 to 7 years, who participated in the TRIXY Early Childhood Study. Behavioral symptoms were assessed through structured behavioral observation and parental questionnaires. Neurocognition was measured using performance tests and psychophysiological measures of arousal. Outcomes showed behavioral symptoms of psychopathology and neurocognitive vulnerabilities, already from an early age. Difficulties in self-regulation tended to become more pronounced with increasing age and were rather robust; independent of karyotype, pre/postnatal diagnosis, or intelligence-levels. A developmental neurocognitive perspective is key in increasing our knowledge of gene-brain-behavior pathways in SCT as well as advancing clinical care (diagnostics and treatment). Self-regulation amongst other neurocognitive functions may serve as a valuable target for early, tailor-made interventions to minimize the risk for psychopathology later in life and improving quality of life. Show less
Gerritsen, R.J.S.; Band, G.P.H.; Lafeber, J.; van den Beukel, N.; van Voskuilen, B.; Hoogland, R. 2023
Cooperation between central banks has been crucial for stabilising the international financial system during the Global Financial Crisis in 2008 and the COVID-19 crisis in 2020. For students of... Show moreCooperation between central banks has been crucial for stabilising the international financial system during the Global Financial Crisis in 2008 and the COVID-19 crisis in 2020. For students of international political economy, understanding why and how central banks cooperate is thus a highly relevant concern. This doctoral dissertation studies central bank cooperation in Europe during and after the Global Financial Crisis. It is based on 25 elite interviews, original archival material and other primary and secondary sources. It reconstructs how central banks came to the decision to conclude credit lines with one another, engaged in Balance-of-Payments assistance programmes, and built new regional institutions to coordinate crisis management and macroprudential policy measures. It finds that central banks motivated their decisions to cooperate not merely on the expected consequences of their actions, but also on their perceptions of appropriateness. Bilateral cooperation was often motivated by norms, such as solidarity, rather than being based predominantly on self-interest; regional financial governance takes the form of inclusive deliberations and consensus-building, rather than clashing national interests. These findings support the conclusions that central banks’ agency, and the ideas that guide their behaviour, need to be better understood to grasp the dynamics of international monetary cooperation. Show less
For people with chronic kidney disease (CKD), adhering to a range of self-management tasks—such as healthy eating, frequent physical activity, and non-smoking—is crucial. However, changing health... Show moreFor people with chronic kidney disease (CKD), adhering to a range of self-management tasks—such as healthy eating, frequent physical activity, and non-smoking—is crucial. However, changing health behaviors is difficult. To support patients in doing so, an eHealth care pathway was developed and evaluated. The results provide different insights into patients' priorities and care needs. Many individuals with CKD experience problems in self-management, which can be hindered by many different barriers of which a common one is psychological distress. Therefore, personalized interventions are needed with screening and treatment of both psychological distress and suboptimal self-management, tailored to the specific barriers and needs of the individual patient. The E-GOAL eHealth care pathway is an example of such a personalized intervention, combining cognitive behavioral therapy with self-management support. Patients were enthusiastic about the eHealth care pathway. However, in a randomized study, the intervention was not effective in reducing psychological distress compared with regular care only. Patients did experience improvements in areas of functioning and self-management that they prioritized themselves. These mixed results show that interventions could be implemented that are person-tailored, with personalized outcomes that reflect individually meaningful treatment goals and improvements for every patient. Show less
This thesis describes the impact of Sex Chromosome Trisomies (SCT; XXX, XXY, XYY) on early social cognition. Individuals with SCT have an increased vulnerability for developing challenges on the... Show moreThis thesis describes the impact of Sex Chromosome Trisomies (SCT; XXX, XXY, XYY) on early social cognition. Individuals with SCT have an increased vulnerability for developing challenges on the social domain, given the convergent impact of the X and Y chromosome on brain networks that underly social adaptive development. We found that already from a very early age on, SCT can be associated with increased risk for vulnerabilities in social interactions, and with increased levels of social impairments associated with ASD. These findings suggest that SCT impact the maturation of the social brain already from an early age, and stresses the importance of early routine monitoring and (preventive) support of early social development in young children with SCT. Show less
The societal toll and human misery associated with mental health disorders is well established. Nonetheless, only about one in five minors with mental health difficulties access adequate... Show moreThe societal toll and human misery associated with mental health disorders is well established. Nonetheless, only about one in five minors with mental health difficulties access adequate professional support. Care pathways and procedures have to facilitate timely recognition and adequate evaluation of patients’ needs to navigate those who can benefit towards ‘the right service in the right place, at the right time, and delivered by the right person’ - a meaningful Chinese proverb often used by authors from the field of healthcare. To reach this meaningful goal, professionals should be able to ‘look’ at a patient and ‘see’ patients’ needs. This by relying on their sufficient knowledge to recognize a probable mental health need, their skills and experience to enquire further, known methods to reliably assess strengths and weaknesses, and readily available resources to translate what they see into an adequate support or management plan. In this PhD thesis we present a series of studies aimed to fill gaps in empirical knowledge on this topic of recognition, assessment, and referral of youth with mental health problems at the interface of primary care and mental healthcare. The results of the studies could inform clinicians on the status quo considering recognition and referral of minors with mental health problems. Moreover, the findings could serve policy and curriculum makers, thereby improving effective practices in child and adolescent mental healthcare. Show less
The overarching goal of this dissertation was to investigate parenting processes in relation to affective well-being in families in the daily flow of life from different perspectives (i.e.,... Show moreThe overarching goal of this dissertation was to investigate parenting processes in relation to affective well-being in families in the daily flow of life from different perspectives (i.e., adolescent, mother, father), on different levels (i.e., objective, momentary, and daily), and in a clinical sample (families with an adolescent with a depression) in addition to community samples. Our findings underline the importance of daily parental warmth and criticism of mothers and fathers for adolescents’ well-being. In addition, we showed that adolescents, parents, and their perceptions of parenting influence each other and that becoming more attuned to each other’s intention and needs is essential. Importantly, we consistently demonstrated that not only the extent and direction of the dynamic processes between parenting and affect in daily life differs between, but also within persons and families. This stresses the need for research focusing on individual processes and combining quantitative with qualitative measures. The use of more idiographic approaches would not only enable gaining more insight into these differences between individuals, but also contribute to identifying parenting practices that work for almost all adolescents. This would facilitate the development of interventions combining universal parenting principles with suggestions for tailoring it to individual- or family-specific situations. Show less
This dissertation reveals that sound financial decisions are determined by multiple factors and are germane to both financial satisfaction and financial well-being. The most promising factors to... Show moreThis dissertation reveals that sound financial decisions are determined by multiple factors and are germane to both financial satisfaction and financial well-being. The most promising factors to increase financial satisfaction were financial confidence, future orientation, and perceived behavioural control, and the most promising factors to increase financial well-being were the combination of high objective and high subjective financial knowledge and financial self-efficacy. We also found two observations remarkable. First, not all financial behaviours that could be intuitively regarded as positive were immediately beneficial to financial satisfaction or financial well-being. For example, budgeting and making considered purchases could be unpleasant and, therefore, adversely affect financial well-being in the short term. Likewise, adjusting spending based on changing (financial) circumstances and keeping track of expenses could be painful and, hence, adversely impacted financial satisfaction in the short term. Second, not all control skills that could be expected to help people make sound financial decisions, actually do so. For instance, people with more spending self-control reported working less toward their financial goals. It is possible that these people are so focused on curbing purchase impulses, that they forget what they are doing it for, namely to create financial room to achieve their goals. Show less
Creating an optimal start during the first 1,000 days of children is an important focus for researchers and policy makers. Parents can positively influence child development through sensitive... Show moreCreating an optimal start during the first 1,000 days of children is an important focus for researchers and policy makers. Parents can positively influence child development through sensitive parenting, which is the ability to understand and promptly and adequately respond to a child’s signals. This thesis provides insight in the development of sensitive parenting from infancy to toddlerhood in primiparous mothers and fathers through longitudinal data from the Netherlands, United Kingdom, and United States. The results demonstrate that fathers and mothers respond more sensitively to their baby in more ecologically valid contexts, i.e. during situations more representative of their daily reality, than in less ecologically valid contexts. Therefore, we recommend to take context into account when parenting skills are studied and evaluated. Next, we made a first step towards clarity on the way parents reflect on the parent-child relationship during the transition to parenthood and in relation to parental sensitivity. We found weak evidence for the theorized link between this reflection and parental sensitivity. Finally, we found that mothers and fathers are equally sensitive across the first two years, and sensitivity levels during this period increase in both parents, indicating that mothers and fathers actually do become better in sensitive parenting. Show less
This dissertation focuses on an understudied yet common phenomenon: the youth wings of political parties. As Western democracies are characterised by party-related political change, the question is... Show moreThis dissertation focuses on an understudied yet common phenomenon: the youth wings of political parties. As Western democracies are characterised by party-related political change, the question is whether the functioning of party youth wings has changed over time. This study compares the functioning of Dutch party youth wings in the years 1985-1990, a period on the eve of major political changes, with the recent years 2014-2020. Using a combination of qualitative and quantitative research methods, it provides insight into the ability of party youth wings to mobilise, represent and socialise young people into the political system. Show less
This thesis aimed to lay the foundation for a new set of Dutch mental health instruments to measure depression and anxiety in an efficient, reliable, valid, and responsive manner. More specifically... Show moreThis thesis aimed to lay the foundation for a new set of Dutch mental health instruments to measure depression and anxiety in an efficient, reliable, valid, and responsive manner. More specifically, the Dutch-Flemish PROMIS adult v1.0 item banks for Depression and Anxiety were psychometrically evaluated for computerized adaptive test (CAT) administration in the Dutch clinical and general population. CAT is a modern methodology that can be used to develop instruments that measure both efficiently and reliably as only the most appropriate questions are administered, and assessment terminates as soon as sufficient reliability is achieved. For the PROMIS CAT instruments, this was demonstrated in the thesis: measuring depression and anxiety in Dutch persons was highly efficient and reliable. Moreover, the CAT instruments were shown to measure depression and anxiety sufficiently responsive and valid as well. This even includes longitudinal validity, which has barely been studied for other Dutch mental health instruments. Overall, it was concluded that the new instruments are an improvement over available instruments. Therefore, using the PROMIS CAT instruments in clinical practice may lead to more efficient and reliable measurement that supports professionals and patients in evaluating patients' treatment. Show less
Center-based child care settings are a common form of non-parental child care for many families worldwide. However, according to earlier studies, children can experience stress when they attend... Show moreCenter-based child care settings are a common form of non-parental child care for many families worldwide. However, according to earlier studies, children can experience stress when they attend child care. The aim of the current dissertation was to elucidate the correlates of physiological and behavioral stress (especially around transitions) for young children (aged 0 – 4 years, with a specific focus on infants) and their parents in the context of center-based child care, and to examine whether and how we can support families with the aim of reducing stress. We did this by conducting a meta-analysis, a large-scale correlational study, and a small-scale intervention study combining questionnaires, observations, and physiological measures. Results showed that a significant part of children and parents experienced stress during and beyond the transition to center-based child care, irrespective of the quality of child care, and that several child (age and number of hours at child care) and parental (sensitivity and separation anxiety) factors were correlated. We also identified some clues as to what type of support can be helpful to assist families within this context, with the ultimate goal of promoting well-being in both young children and their parents. Show less
Increasingly code and algorithms are techniques also applied in textual scholarship, giving rise to new interactions between software engineers and textual scholars. This book argues that much of... Show moreIncreasingly code and algorithms are techniques also applied in textual scholarship, giving rise to new interactions between software engineers and textual scholars. This book argues that much of that process and its effects on textual scholarship are still poorly understood and go unchecked by otherwise normal processes of quality control in scholarship such as peer review. The text provides case studies in which some of these interactions become more apparent, as well as the academic challenges and problems that they introduce. The book demonstrates that the space between code creation and conventional scholarship is one that offers many affordances to textual scholarship that until now remain unexplored. The author argues that it is an intellectual obligation of programmers and textual scholars to examine the properties of digital text and how its existence changes and challenges textual scholarship. Show less
This dissertation describes the findings of six studies on mental health problems in the family context, specifically focusing on the associations with the parent-child relationship, parenting... Show moreThis dissertation describes the findings of six studies on mental health problems in the family context, specifically focusing on the associations with the parent-child relationship, parenting behaviors and experiences of childhood maltreatment. The aim is to better understand the risk factors, development and transmission of common psychological problems in order to contribute to prevention and treatment strategies for common psychological problems such as anxiety and depression.Overall, the findings underline the importance of the family context in the development and levels of mental health problems. In addition to the impact of one's own negative parenting experiences, including lack of warmth and experiences of emotional or physical abuse, negative parenting experiences of one's siblings are also associated with elevated anxiety and depressive symptom levels.We also found that externalizing problems of fathers and children have a negative impact on the parent-child interactions. In addition, we found that children with behavioral problems during early adolescence experience harsher parental discipline, even three years later.In the current treatment guidelines for common mental disorders, most therapies focus on the individual. An (additional) systemic approach and considering past and present family relationships in therapy, can be of additional value. For example, supporting families with interventions to improve the parent-child relationship can be helpful in the short and long term. Moreover, (early) treatment of psychological and behavioral problems of the parent or child might be beneficial for all family members. Show less
This PhD research dealt with neurobiological and behavioral aspects of pain. Previous research has demonstrated that pain sensitivity can be worsened as a result of learned negative expectations, a... Show moreThis PhD research dealt with neurobiological and behavioral aspects of pain. Previous research has demonstrated that pain sensitivity can be worsened as a result of learned negative expectations, a phenomenon termed nocebo hyperalgesia –a counterpart to placebo analgesia. This PhD dissertation describes neuroimaging and biobehavioral experimental studies as well as a review and a meta-analysis concerned with such learned effects on pain. The research adds to a growing literature that has been challenging antiquated understandings of pain as a bottom-up process. We conducted a series of biobehavioral studies to further our understanding of how bottom-up pain signaling can be influenced by top-down processing. We examined the types of experiences, such as receiving negative information or experiencing a negative effect first-hand, that may lead to stronger nocebo effects. Behavioral paradigms were used to model real-life pain experiences, through validated methods, novel learning manipulations, as well as a close examination of emotional correlates such as fear. Concurrently, innovative neuroscientific methods –including pharmacological manipulations– were used to examine the biobehavioral underpinnings of learned nocebo responses. Our findings add to the growing knowledgebase from the field of nocebo hyperalgesia, demonstrating that learning by experience can decisively influence the processing and perception of noxious stimuli. Show less
Children with SCT have an increased vulnerability for adverse neurobehavioral outcomes and an increased risk for neurocognitive difficulties in the language and communication domain. This... Show moreChildren with SCT have an increased vulnerability for adverse neurobehavioral outcomes and an increased risk for neurocognitive difficulties in the language and communication domain. This vulnerability starts from a young age and may increase when children get older. Neurocognitive functions within the language and communication domain serve as early markers of at-risk pathways with unfavorable neurobehavioral outcomes. These findings come with important clinical implications for the SCT population andwill ideally fuel the implementation of early monitoring, and implementation and development of preventive support and intervention. Show less
