BackgroundResearch in depression has progressed rapidly over the past four decades. Yet depression rates are not subsiding and treatment success is not improving. We examine the extent to which the... Show moreBackgroundResearch in depression has progressed rapidly over the past four decades. Yet depression rates are not subsiding and treatment success is not improving. We examine the extent to which the gap between science and practice is associated with the level of integration in how depression is considered in research and stakeholder-relevant documents.MethodsWe used a network-science perspective to analyze similar uses of depression relevant terms in the Google News corpus (approximately 1 billion words) and the Web of Science database (120 000 documents).ResultsThese analyses yielded consistent pictures of insular modules associated with: (1) patient/providers, (2) academics, and (3) industry. Within academia insular modules associated with psychology, general medical, and psychiatry/neuroscience/biology were also detected.ConclusionsThese analyses suggest that the domain of depression is fragmented, and that advancements of relevance to one stakeholder group (academics, industry, or patients) may not translate to the others. We consider potential causes and associated responses to this fragmentation that could help to unify and advance translation from research on depression to the clinic, largely involving harmonizing employed language, bridging conceptual domains, and increasing communication across stakeholder groups. Show less
Endendijk, J.J.; Smit, A.K.; van Baar, A.L.; Bos, P.A. 2019
This study examined 1) mothers' neural responses to pictures of boys and girls who confirmed or violated social expectations regarding toy preferences, and 2) whether neural sensitivity to targets... Show moreThis study examined 1) mothers' neural responses to pictures of boys and girls who confirmed or violated social expectations regarding toy preferences, and 2) whether neural sensitivity to targets that violated gendered expectations interacted with mothers' gender stereotypes. In an event-related fMRI experiment, 23 mothers of a 2-6 year-old child viewed and evaluated pictures of boys or girls with their favorite toy. Next, mothers gender stereotypes about children's toys and behavior, and internal motivation to behave without prejudice were assessed. Several neural processes were underlying parents' responses to children's behavior that violates gender-role expectations. Brain regions involved in mentalizing or storage of social knowledge, understanding goal-directed behavior, behavioral control, and conflict monitoring were activated when viewing child targets that violated gender expectations. In these brain areas, increased neural responses to targets that violated traditional gender expectations were associated with more stereotyped expectations about boys' and girls' toys and behavior. Show less
Bogomolova, K.; Ham, I.J.M. van der; Dankbaar, M.E.W.; Broek, W.W. van den; Hovius, S.E.R.; Hage, J.A. van der; Hierck, B.P. 2019
BackgroundFrontotemporal dementia (FTD) and Alzheimer's disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However,... Show moreBackgroundFrontotemporal dementia (FTD) and Alzheimer's disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what disease stage these differences emerge. Here, we investigate whether divergent differences in grey matter volume, white matter diffusion, and functional connectivity are already apparent between cognitively healthy carriers of pathogenic FTD mutations, and cognitively healthy carriers at increased AD risk.MethodsWe acquired multimodal magnetic resonance imaging (MRI) brain scans in cognitively healthy subjects with (n=39) and without (n=36) microtubule-associated protein Tau (MAPT) or progranulin (GRN) mutations, and with (n=37) and without (n=38) apolipoprotein E epsilon 4 (APOE4) allele. We evaluated grey matter volume using voxel-based morphometry, white matter diffusion using tract-based spatial statistics (TBSS), and region-to-network functional connectivity using dual regression in the default mode network and salience network. We tested for differences between the respective carriers and controls, as well as for divergence of those differences. For the divergence contrast, we additionally performed region-of-interest TBSS analyses in known areas of white matter diffusion differences between FTD and AD (i.e., uncinate fasciculus, forceps minor, and anterior thalamic radiation).ResultsMAPT/GRN carriers did not differ from controls in any modality. APOE4 carriers had lower fractional anisotropy than controls in the callosal splenium and right inferior fronto-occipital fasciculus, but did not show grey matter volume or functional connectivity differences. We found no divergent differences between both carrier-control contrasts in any modality, even in region-of-interest analyses.ConclusionsConcluding, we could not find differences suggestive of divergent pathways of underlying FTD and AD pathology in asymptomatic risk mutation carriers. Future studies should focus on asymptomatic mutation carriers that are closer to symptom onset to capture the first specific signs that may differentiate between FTD and AD. Show less
BackgroundFrontotemporal dementia (FTD) and Alzheimer's disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However,... Show moreBackgroundFrontotemporal dementia (FTD) and Alzheimer's disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what disease stage these differences emerge. Here, we investigate whether divergent differences in grey matter volume, white matter diffusion, and functional connectivity are already apparent between cognitively healthy carriers of pathogenic FTD mutations, and cognitively healthy carriers at increased AD risk.MethodsWe acquired multimodal magnetic resonance imaging (MRI) brain scans in cognitively healthy subjects with (n=39) and without (n=36) microtubule-associated protein Tau (MAPT) or progranulin (GRN) mutations, and with (n=37) and without (n=38) apolipoprotein E epsilon 4 (APOE4) allele. We evaluated grey matter volume using voxel-based morphometry, white matter diffusion using tract-based spatial statistics (TBSS), and region-to-network functional connectivity using dual regression in the default mode network and salience network. We tested for differences between the respective carriers and controls, as well as for divergence of those differences. For the divergence contrast, we additionally performed region-of-interest TBSS analyses in known areas of white matter diffusion differences between FTD and AD (i.e., uncinate fasciculus, forceps minor, and anterior thalamic radiation).ResultsMAPT/GRN carriers did not differ from controls in any modality. APOE4 carriers had lower fractional anisotropy than controls in the callosal splenium and right inferior fronto-occipital fasciculus, but did not show grey matter volume or functional connectivity differences. We found no divergent differences between both carrier-control contrasts in any modality, even in region-of-interest analyses.ConclusionsConcluding, we could not find differences suggestive of divergent pathways of underlying FTD and AD pathology in asymptomatic risk mutation carriers. Future studies should focus on asymptomatic mutation carriers that are closer to symptom onset to capture the first specific signs that may differentiate between FTD and AD. Show less
Cognitive behavioral therapy (CBT) is often effective in the treatment of school refusal (SR). Its usefulness is limited, however, if youth displaying SR also refuse to attend treatment sessions.... Show moreCognitive behavioral therapy (CBT) is often effective in the treatment of school refusal (SR). Its usefulness is limited, however, if youth displaying SR also refuse to attend treatment sessions. In these cases parents and school staff may consider using school-based interventions that do not rely on face-to-face assessment and treatment with the young person. The current study examined the effectiveness of a school-based intervention applied in Japan to achieve rapid return to school among adolescents displaying SR. Between 2009 and 2015, the parents of 62 adolescents displaying SR were invited to implement a school-based rapid return approach. Thirty-nine parents agreed to implement the approach and 23 decided to wait until their child spontaneously attended school. Of the 39 cases in which the approach was implemented, 28 adolescents (72%) resumed attendance at their original school, 2 (5%) transferred to another school, and 9 (23%) did not resume attendance. In contrast, all 23 non-intervention cases continued to refuse to attend school for 3 months or longer, and none of these adolescents returned to regular school attendance within 9 months. This study tentatively suggests that the rapid return approach may be an effective form of intervention for adolescents displaying SR and simultaneously refusing to attend individual therapy. Because this approach is ethically complex, involving forced school attendance in adolescence, it should only be employed under specific circumstances. These circumstances are discussed. Show less
Objective: Unmet health care needs require additional care resources to achieve optimal patient well-being. In this nationwide study we examined associations between a number of risk factors and... Show moreObjective: Unmet health care needs require additional care resources to achieve optimal patient well-being. In this nationwide study we examined associations between a number of risk factors and unmet needs after treatment among women with breast cancer, while taking into account their health care practices. We expected that more care use would be associated with lower levels of unmet needs. Methods: A multicenter, prospective, observational design was employed. Women with primary breast cancer completed questionnaires 6 and 15 months post-diagnosis. Medical data were retrieved from medical records. Direct and indirect associations between sociodemographic and clinical risk factors, distress, care use, and unmet needs were investigated with structural equation modeling. Results: Seven hundred forty-six participants completed both questionnaires (response rate 73.7%). The care services received were not negatively associated with the reported levels of unmet needs after treatment. Comorbidity was associated with higher physical and daily living needs. Higher age was associated with higher health system-related and informational needs. Having had chemotherapy and a mastectomy were associated with higher sexuality needs and breast cancer-specific issues, respectively. A higher level of distress was associated with higher levels of unmet need in all domains. Conclusions: Clinicians may use these results to timely identify which women are at risk of developing specific unmet needs after treatment. Evidence-based, cost-effective (online) interventions that target distress, the most influential risk factor, should be further implemented and disseminated among patients and clinicians. Show less
Vrijhof, C.I.; Euser, S.; Bakermans-Kranenburg, M.J.; Bulk, B.G. van den; Bosdriesz, J.R.; Linting, M.; ... ; Van IJzendoorn, M.H. 2019
Abstract Societal impact of research does not occur primarily as unexpected extraordinary incidents of particularly useful breakthroughs in science. It is more often a result of normal everyday... Show moreAbstract Societal impact of research does not occur primarily as unexpected extraordinary incidents of particularly useful breakthroughs in science. It is more often a result of normal everyday interactions between organizations that need to create, exchange, and make use of new knowledge to further their goals. We use the distinctions between normal and extraordinary societal impact and between organizational- and individual-level activities and responsibilities to discuss how science–society relations can better be understood, evaluated, and improved by focusing on the organizations that typically interact in a specific domain of research. Show less
Background: Treatment with 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) and dietary phenylalanine and tyrosine restriction improves physical health and life expectancy in... Show moreBackground: Treatment with 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC) and dietary phenylalanine and tyrosine restriction improves physical health and life expectancy in Tyrosinemia type 1 (TT1). However, neurocognitive outcome is suboptimal. This study aimed to investigate behavior problems and health-related quality of life (HR-QoL) in NTBC-dietary-treated TT1 and to relate this to phenylalanine and tyrosine concentrations.Results: Thirty-one TT1 patients (19 males; mean age 13.9 ± 5.3 years) were included in this study. Emotional and behavioral problems, as measured by the Achenbach System of Empirically Based Assessment, were present in almost all domains. Attention and thought problems were particularly evident. HR-QoL was assessed by the TNO AZL Children’s and Adults QoL questionnaires. Poorer HR-QoL as compared to reference populations was observed for the domains: independent daily functioning, cognitive functioning and school performance, social contacts, motor functioning, and vitality. Both internalizing and externalizing behavior problems were associated with low phenylalanine (and associated lower tyrosine) concentrations during the first year of life. In contrast, high tyrosine (and associated higher phenylalanine) concentrations during life and specifically the last year before testing were associated with more internalizing behavior and/or HR-QoL problems.Conclusions: TT1 patients showed several behavior problems and a lower HR-QoL. Associations with metabolic control differed for different age periods. This suggests the need for continuous fine-tuning and monitoring of dietary treatment to keep phenylalanine and tyrosine concentrations within target ranges in NTBC-treated TT1 patients. Show less
This article explores how notions of citizenship are negotiated in encounters between parents and youth care professionals in Amsterdam in the context of heated debates over citizenship and... Show moreThis article explores how notions of citizenship are negotiated in encounters between parents and youth care professionals in Amsterdam in the context of heated debates over citizenship and belonging. We draw on ethnographic research on Egyptian migrant parents' interactions with the welfare state, and on the work of youth care professionals. We found that both parents and professionals were invested in universal forms of citizenship. Parents wanted to be treated like their fellow citizens regardless of their background, while professionals wanted to care for all children. While parents feared and suspected that their children were subject to unfair treatment, professional practices left little space for disagreement or a consideration of racialized aspects of their encounters with clients. We conclude that notions of equal citizenship provide a primary, but uncertain ground for the elaboration of citizenship and belonging in parenting encounters, which is haunted by the spectre of difference and inequality. Show less
This article explores how notions of citizenship are negotiated in encounters between parents and youth care professionals in Amsterdam in the context of heated debates over citizenship and... Show moreThis article explores how notions of citizenship are negotiated in encounters between parents and youth care professionals in Amsterdam in the context of heated debates over citizenship and belonging. We draw on ethnographic research on Egyptian migrant parents' interactions with the welfare state, and on the work of youth care professionals. We found that both parents and professionals were invested in universal forms of citizenship. Parents wanted to be treated like their fellow citizens regardless of their background, while professionals wanted to care for all children. While parents feared and suspected that their children were subject to unfair treatment, professional practices left little space for disagreement or a consideration of racialized aspects of their encounters with clients. We conclude that notions of equal citizenship provide a primary, but uncertain ground for the elaboration of citizenship and belonging in parenting encounters, which is haunted by the spectre of difference and inequality. Show less
ObjectivesTo explore possible working mechanisms of anxiety reduction in women with anxiety disorders, treated with art therapy (AT).MethodsA RCT comparing AT versus waiting list (WL) condition on... Show moreObjectivesTo explore possible working mechanisms of anxiety reduction in women with anxiety disorders, treated with art therapy (AT).MethodsA RCT comparing AT versus waiting list (WL) condition on aspects of self-regulation. Stress regulation (heart rate and heart rate variability) and executive functioning (daily behavioural and cognitive performance aspects of executive functioning (EF)) were evaluated in a pre-post design. Participants were women, aged 18–65 years with moderate to severe anxiety symptoms.ResultsEffectiveness of AT compared to WL was demonstrated in a higher resting HRV post treatment, improvements in aspects of self-reported daily EF (emotion control, working memory, plan/organize and task monitor), but not in cognitive performance of EF, stress responsiveness and down regulation of stress. The decrease in anxiety level was associated with improvements in self-reported daily EF.ConclusionsAT improves resting HRV and aspects of EF, the latter was associated with art therapy-related anxiety reduction Show less
While conflict event data sets are increasingly used in contemporary conflict research, important concerns persist regarding the quality of the collected data. Such concerns are not necessarily new... Show moreWhile conflict event data sets are increasingly used in contemporary conflict research, important concerns persist regarding the quality of the collected data. Such concerns are not necessarily new. Yet, because the methodological debate and evidence on potential errors remains scattered across different subdisciplines of social sciences, there is little consensus concerning proper reporting practices in codebooks, how best to deal with the different types of errors, and which types of errors should be prioritised. In this article, we introduce a new analytical framework—that is, the Total Event Error (TEE) framework—which aims to elucidate the methodological challenges and errors that may affect whether and how events are entered into conflict event data sets, drawing on different fields of study. Potential errors are diverse and may range from errors arising from the rationale of the media source (e.g., selection of certain types of events into the news) to errors occurring during the data collection process or the analysis phase. Based on the TEE framework, we propose a set of strategies to mitigate errors associated with the construction and use of conflict event data sets. We also identify a number of important avenues for future research concerning the methodology of creating conflict event data sets. Show less
We present a consensus-based checklist to improve and document the transparency of research reports in social and behavioural research. An accompanying online application allows users to complete... Show moreWe present a consensus-based checklist to improve and document the transparency of research reports in social and behavioural research. An accompanying online application allows users to complete the form and generate a report that they can submit with their manuscript or post to a public repository. Show less
Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and... Show moreIdentifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within this narrative review, we conducted a comprehensive review of neuroimaging studies of STBs published to date and summarize the progress achieved on elucidating neurobiological substrates of STBs, with a focus on converging findings across studies. We review neuroimaging evidence across differing mental disorders for structural, functional, and molecular alterations in association with STBs, which converges particularly in regions of brain systems that subserve emotion and impulse regulation including the ventral prefrontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in the connections between these brain areas. The reviewed literature suggests that impairments in medial and lateral VPFC regions and their connections may be important in the excessive negative and blunted positive internal states that can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors. A combination of VPFC and DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning. The dorsal anterior cingulate cortex and insula may play important roles in switching between these VPFC and DPFC systems, which may contribute to the transition from suicide thoughts to behaviors. Future neuroimaging research of larger sample sizes, including global efforts, longitudinal designs, and careful consideration of developmental stages, and sex and gender, will facilitate more effectively targeted preventions and interventions to reduce loss of life to suicide. Show less
