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Krol, L.; Remmerswaal, L.; Groen, M.; Beek, J.G. van der; Sikkema, R.S.; Dellar M.E.; ... ; Schrama M.J.J. 2026

Landscape level associations between birds, mosquitoes and microclimates: possible consequences for disease transmission?

Article / Letter to editor

open access

Kalkreuth, R.T.; Vasicek, Z.; Husa, J.; Vermetten, D.L.; Ye, F.; Bäck, T.H.W. 2025

General Boolean function benchmark suite

Article in monograph or in proceedings

open access

Robinson-Garcia, N., Corona-Sobrino, C., Chinchilla-Rodríguez, Z., Torres-Salinas, D.; Costas Comesana, R. 2025

Informetric methods for studying the diversity of the scientific workforce: towards a state-of-the-art

Event

metadata only

Tulp, T.; Tietema, A.; Loon, E.E. van; Ebben, B.; Hall, R.L. van; Son, Mm. van; Barmentlo, S.H. 2025

Biomonitoring of dairy farm emitted ammonia in surface waters using phytoplankton and periphyton

Article / Letter to editor

open access

Welander, N.Z.; Rukh, G.; Rask-Andersen, M.; Harder, A.V.E.; Maagdenberg, A.M.J.M. van den; Schioth, H.B.; ... ; Int Headache Genetics Consortium 2025

Migraine, inflammatory bowel disease and celiac disease: a Mendelian randomization study

Article / Letter to editor

open access

ObjectiveTo assess whether migraine may be genetically and/or causally associated with inflammatory bowel disease (IBD) or celiac disease.BackgroundMigraine has been linked to IBD and celiac... Show moreObjectiveTo assess whether migraine may be genetically and/or causally associated with inflammatory bowel disease (IBD) or celiac disease.BackgroundMigraine has been linked to IBD and celiac disease in observational studies, but whether this link may be explained by a shared genetic basis or could be causal has not been established. The presence of a causal association could be clinically relevant, as treating one of these medical conditions might mitigate the symptoms of a causally linked condition.MethodsLinkage disequilibrium score regression and two-sample bidirectional Mendelian randomization analyses were performed using summary statistics from cohort-based genome-wide association studies of migraine (59,674 cases; 316,078 controls), IBD (25,042 cases; 34,915 controls) and celiac disease (11,812 or 4533 cases; 11,837 or 10,750 controls). Migraine with and without aura were analyzed separately, as were the two IBD subtypes Crohn's disease and ulcerative colitis. Positive control analyses and conventional Mendelian randomization sensitivity analyses were performed.ResultsMigraine was not genetically correlated with IBD or celiac disease. No evidence was observed for IBD (odds ratio [OR] 1.00, 95% confidence interval [CI] 0.99–1.02, p = 0.703) or celiac disease (OR 1.00, 95% CI 0.99–1.02, p = 0.912) causing migraine or migraine causing either IBD (OR 1.08, 95% CI 0.96–1.22, p = 0.181) or celiac disease (OR 1.08, 95% CI 0.79–1.48, p = 0.614) when all participants with migraine were analyzed jointly. There was some indication of a causal association between celiac disease and migraine with aura (OR 1.04, 95% CI 1.00–1.08, p = 0.045), between celiac disease and migraine without aura (OR 0.95, 95% CI 0.92–0.99, p = 0.006), as well as between migraine without aura and ulcerative colitis (OR 1.15, 95% CI 1.02–1.29, p = 0.025). However, the results were not significant after multiple testing correction.ConclusionsWe found no evidence of a shared genetic basis or of a causal association between migraine and either IBD or celiac disease, although we obtained some indications of causal associations with migraine subtypes. Show less

Shalgunov, V.; Broek, S.L. van den; Andersen, I.V.; Raval, N.R.; Schäfer, G.; Barz, M.; ... ; Battisti, U.M. 2024

Evaluation of F-537-Tetrazine in a model for brain pretargeting imaging: comparison to N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine

Article / Letter to editor

open access

Brain pretargeted nuclear imaging for the diagnosis of various neurodegenerative diseases is a quickly developing field. The tetrazine ligation is currently the most explored approach to achieve... Show moreBrain pretargeted nuclear imaging for the diagnosis of various neurodegenerative diseases is a quickly developing field. The tetrazine ligation is currently the most explored approach to achieve this goal due to its remarkable properties. In this work, we evaluated the performance of F-537-Tetrazine, previously developed by Biogen, and N-(3-[18F]fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine, previously developed in our group, thereby allowing for the direct comparison of these two imaging probes. The evaluation included synthesis, radiolabeling and a comparison of the physicochemical properties of the compounds. Furthermore, their performance was evaluated by in vitro and in vivo pretargeting models. This study indicated that N-(3-[18F] fluoro-5-(1,2,4,5-tetrazin-3-yl)benzyl)propan-1-amine might be more suited for brain pretargeted imaging. Show less

Nagtzaam, M.A.M.; Louwerse, T.P. 2024

Geographical representation under a single nationwide district: the case of the Netherlands

Article / Letter to editor

open access

Previous studies have demonstrated the common occurrence of constituency focus in parliamentary questions, which is most often attributed to electoral incentives. If an electoral system makes use... Show morePrevious studies have demonstrated the common occurrence of constituency focus in parliamentary questions, which is most often attributed to electoral incentives. If an electoral system makes use of a single nationwide district, however, these district-oriented electoral incentives do not apply. MPs may still substantively represent a geographical region, because they are motivated to stand up for a specific region for other reasons. This article explores the extent to which Dutch MPs pay attention in parliamentary questions and debates to specific regions. We find that those with stronger ties to a region, and especially MPs who reside in a region, are more likely to mention it in parliamentary questions and speeches. In addition, we find that this effect is stronger for provinces where regional attachment among residents is relatively stronger. Show less

Baca, M.; Popović, D.; Agadzhanyan, A.K.; Baca, K.; Conard, N.J.; Fewlass, H.; ... ; Nadachowski, A. 2024

Ancient DNA of narrow-headed vole reveal common features of the Late Pleistocene population dynamics in cold-adapted small mammals

Article / Letter to editor

open access

The narrow-headed vole, collared lemming and common vole were the most abundant small mammal species across the Eurasian Late Pleistocene steppe-tundra environment. Previous ancient DNA studies of... Show moreThe narrow-headed vole, collared lemming and common vole were the most abundant small mammal species across the Eurasian Late Pleistocene steppe-tundra environment. Previous ancient DNA studies of the collared lemming and common vole have revealed dynamic population histories shaped by climatic fluctuations. To investigate the extent to which species with similar adaptations share common evolutionary histories, we generated a dataset comprised the mitochondrial genomes of 139 ancient and 6 modern narrow-headed voles from several sites across Europe and northwestern Asia covering approximately the last 100 thousand years (kyr). We inferred Bayesian time-aware phylogenies using 11 radiocarbon-dated samples to calibrate the molecular clock. Divergence of the main mtDNA lineages across the three species occurred during marine isotope stages (MIS) 7 and MIS 5, suggesting a common response of species adapted to open habitat during interglacials. We identified several time-structured mtDNA lineages in European narrow-headed vole, suggesting lineage turnover. The timing of some of these turnovers was synchronous across the three species, allowing us to identify the main drivers of the Late Pleistocene dynamics of steppe- and cold-adapted species. Show less

Vriens, D.; Koster, E.J. de; Geus-Oei, L.F. de; Oyen, W.J.G.; EfFECTS trial consortium 2024

Preoperative stratification of cytologically indeterminate thyroid nodules by [18F]FDG-PET: can Orpheus bring back Eurydice?

Article / Letter to editor

open access

Marciello, M.; Cusati, V.; Nicolosi, F.; Saavedra-Rubio, K.; Pierrat, E.; Thonemann, N.; Laurent, A. 2024

Evaluating the economic landscape of hybrid-electric regional aircraft: a cost analysis across three time horizons

Article / Letter to editor

under embargo until 2025-01-16

This article presents the results of a prospective cost analysis of future regional aviation solutions, specifically focusing on hybrid-electric regional aircraft for 50 passengers. The study spans three time horizons (short term, medium term, long term) and employs a validated workflow to estimate costs for various solutions, including conventional, hybrid-electric, and hydrogen-based architectures. A specialized cost model is introduced to assess the electric components of the powertrain, emphasizing maintenance expenses and energy costs. Despite the environmental promise of hybrid and electric solutions, the results reveal significantly higher direct operating costs (up to 69.8%) compared to conventional options. The study highlights the importance of targeted policies to incentivize sustainable alternatives, suggesting potential solutions such as discouraging kerosene-based aircraft and promoting sustainable aviation fuel. These insights provide valuable guidance for industry stakeholders navigating the path toward a more sustainable and economically viable aviation future.

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Iwasaki, N.; Yoshioka, K. 2024

Thinking-for-speaking to describe motion events: English-Japanese bilinguals’ L1 English and L2 Japanese speech and gesture

Part of book or chapter of book

open access

Driessen, E.M.M.A. 2024

Stimulering en facilitering van burgerinitiatieven door de overheid: over de invulling van de ‘dienende overheid’ bij derde generatie burgerparticipatie

Doctoral Thesis

metadata only

Riedinger, M.A.; Mesbah, R.; Koenders, M.A.; Henderickx, J.G.E.; Smits, W.K.; El Filali, E.; ... ; Giltay, E.J. 2024

A healthy dietary pattern is associated with microbiota diversity in recently diagnosed bipolar patients: the Bipolar Netherlands Cohort (BINCO) study

Article / Letter to editor

open access

Kuipers, B.S. 2024

Wat is hier de bedoeling? Tussen eenvoud en meervoud in publiek leiderschap

Inaugural lecture

under embargo until 2024-06-15

Oratie uitgesproken door Prof.dr. Ben S. Kuipers bij de aanvaarding van het ambt van hoogleraar Publiek Leiderschap aan de Universiteit Leiden op vrijdag 14 juni 2024

Spelier, P. 2024

Counting curves and their rational points

Doctoral Thesis

some documents under embargo until 2025-06-12

In this thesis we study curves. In the first half, we study moduli spaces of curves and Gromov-Witten invariants, certain kinds of curves counts. We employ logarithmic geometry for this. Some major... Show moreIn this thesis we study curves. In the first half, we study moduli spaces of curves and Gromov-Witten invariants, certain kinds of curves counts. We employ logarithmic geometry for this. Some major results include the polynomiality of the double ramification cycle and recursive relations for the log double ramification cycle.In the second half we study rational points on curves, in particular Chabauty's method for finding the rational points and extensions of it. Major results include that the geometric (quadratic) Chabauty method is theoretically stronger than the original (quadratic) Chabauty method, and that local heights for quadratic Chabauty are explicitly computable. Show less

Ramble, O.K.C. 2024

Historiography and palaeography of Sasanian Middle Persian inscriptions

Doctoral Thesis

some documents under embargo until 2025-12-11

The research developed in this doctoral dissertation contributes to Sasanian studies in particular, and to ancient Iranian studies more generally, in three main ways. First, it offers a critical... Show moreThe research developed in this doctoral dissertation contributes to Sasanian studies in particular, and to ancient Iranian studies more generally, in three main ways. First, it offers a critical study of the history of research surrounding the decipherment of the Middle Persian script, to define the contribution of Sasanian epigraphy to the broader historiographical debates concerning the study of Late Antiquity. Then, through the palaeographic analysis of the earliest pre-Sasanian and Sasanian Middle Persian written vestiges, it highlights the existence of a lively scribal tradition that was local to Persis in the Seleucid and Parthian periods. Finally, it investigates a possible model for the study of Sasanian inscriptions which takes into account the references made in these monumental texts to (now lost) manuscript documents, as well as to key features of their natural and built environment; this helps bring into sharp focus the often overlooked legal, administrative and religious functions of Sasanian rock-cut texts. Show less

Kurchaba, S. 2024

Machine learning-based NO2 estimation from seagoing ships using TROPOMI/S5P satellite data

Doctoral Thesis

open access

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power... Show moreThe marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing. In contrast, the pollution impact of maritime transport continues to increase. This generates a big societal pressure, resulting in regulations proposed by the International Maritime Organization (IMO). These regulations impose restrictions on emission levels from ships. While various methods are used to assess the emission from ships in ports and off-coastal areas, monitoring over the open sea has been infeasible. The game-changer is the TROPOMI instrument on board the Sentinel 5 Precursor Satellite – studies show that NO2 plumes from some individual seagoing ships can be distinguished on TROPOMI images. The objective of this thesis is to pave the way toward the application of the TROPOMI instrument for the monitoring of compliance of seagoing ships. This is achieved through the fusion of machine learning, feature engineering, and data integration. Each chapter builds upon the findings of its predecessor, as a whole, representing state-of-the-art knowledge in the application of TROPOMI data for the monitoring of NO2 emissions from individual seagoing ships. Show less

Chagnet, N. 2024

Applications of AdS/CFT to strongly correlated matter: from numerics to experiments

Doctoral Thesis

open access

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for... Show moreWhat physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted all traditional methods of understanding. It calls for a complete change in paradigm. An unexpected venue for progress was found in the study of gravity. By studying special gravitational solutions such as black holes and stars made of electrons, it turns out to be possible to shed some light on the physics and transport properties of quantum matter. This analysis relies on the use of high-performance computations to obtain these gravitational solutions, but the payoff is access to uncharted areas of physics. So far, such methods have successfully brought some insight into the flow of energy in such systems, but the flow of electric charge or the quantum information patterns remain shrouded in mystery. The findings of this thesis address key parts of these questions, particularly in the context of black holes as models of exotic quantum metals. Show less

Kempes, M.M. 2024

Jonge breinen in het strafrecht

Inaugural lecture

open access

Oratie uitgesproken door Prof.dr. Maaike M. Kempes bij de aanvaarding van het ambt van bijzonder hoogleraar forensische neuropedagogiek aan de Universiteit Leiden op maandag 10 juni 2024

Navarre, N.H. 2024

Trading Responsibility: navigating national burdens in a globalized world

Doctoral Thesis

some documents under embargo until 2025-12-06

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental... Show moreInternational trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring. This dissertation explores the role of international trade on the environmental impacts of two sectors: the food system and the plastic waste system. For each system, this work finds that international trade leads to unwelcomed tradeoffs. Within the food system, in the form of consumption patterns that have been able to shift towards more land intensive diets. Adopting more autarkic food policies may help shift food consumption back towards diets that are more in line with planetary boundaries while also improving the efficiency of currently underdeveloped food supply chains. Within the plastic waste system, international trade has been detrimental by increasing plastic waste leaking to the aquatic environment, particularly from high-income countries. Recycling policies within these countries have amplified the quantities of plastic waste being exported to reach recycling metrics, ultimately highlighting the need for improved metrics to evaluate the environmental tradeoffs of plastic waste disposal. Show less

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