ObjectiveThere is a continued need for improvement of second-line systemic treatment for metastatic and/or recurrent endometrial cancer.MethodsIn this phase II, open-label study, eligible patients... Show moreObjectiveThere is a continued need for improvement of second-line systemic treatment for metastatic and/or recurrent endometrial cancer.MethodsIn this phase II, open-label study, eligible patients had histologically or cytologically confirmed endometrial cancer, documented progressive disease, and a WHO performance status of <= 2. All participants received treatment with pazopanib 800 mg once daily until progression, unacceptable toxicity, or patient refusal. The primary endpoint was progression-free survival at 3 months, with secondary outcomes of overall response rate, progression-free survival, overall survival, and toxicity. The study was powered to demonstrate 50% progression-free survival at 3 months with alpha=0.05 and beta=80%.ResultsBetween January 2011 and February 2016, 60 eligible patients were included (intention-to-treat population). Median age was 68 (range, 53-85) years. Previous treatment included pelvic radiotherapy (58%), chemotherapy (90%), and hormonal therapy (43%). Three-month progression-free survival was 63.3% in the intention-to-treat population, with median progression-free survival and overall survival of 3.4 and 7.5 months, respectively. Overall response rate was 8.3%, and median follow-up 7.6 months. The most common grade 3 or higher adverse events were gastrointestinal toxicity in 21% of participants, including two patients with a gut perforation, one fatal gastrointestinal hemorrhage, one enterocutaneous fistula, and one fatal enterovaginal fistula. Extensive peritoneal disease existed in 80% of the patients with severe gastrointestinal toxicity. A definite correlation with previous radiotherapy could not be established.ConclusionsPazopanib met its primary endpoint of 3 months' progression-free survival in advanced endometrial cancer (63.3%), but response rates were modest. There may be a correlation for rare but severe gastrointestinal toxicity with previous treatments and/or disease site that has yet to be elucidated. Show less
The Indo-European u-stem nouns merged almost completely with the o-stems in all Slavic languages. In every Slavic language, their combined paradigm shows traces of both original sets of endings.... Show moreThe Indo-European u-stem nouns merged almost completely with the o-stems in all Slavic languages. In every Slavic language, their combined paradigm shows traces of both original sets of endings. The merger of the two paradigms began before the earliest attestations of Slavic, but the attested evidence allows us to determine that the paradigms must have been distinct in late Common Slavic. The original distribution between u- and o-stems was blurred when they started to merge. The endings were redistributed on the basis of phonological and semantic criteria. In this paper it is argued that a similar process took place in the accentuation of masculine o- and u-stems in Slavic. The accentual phenomena discussed here have alternatively been explained as reflexes of a Proto-Slavic accentual pattern referred to as accent paradigm d. Show less
From genocide, forced displacement, and emigration, to the gradual establishment of sedentary and rooted global communities, how has the Armenian diaspora formed and maintained a sense of... Show moreFrom genocide, forced displacement, and emigration, to the gradual establishment of sedentary and rooted global communities, how has the Armenian diaspora formed and maintained a sense of collective identity? This book explores the richness and magnitude of the Armenian experience through the 20th century to examine how Armenian diaspora elites and their institutions emerged in the post-genocide period and used “stateless power” to compose forms of social discipline. Historians, cultural theorists, literary critics, sociologists, political scientists, and anthropologists explore how national and transnational institutions were built in far-flung sites from Istanbul, Aleppo, Beirut and Jerusalem to Paris, Los Angeles, and the American mid-west. Exploring literary and cultural production as well as the role of religious institutions, the book probes the history and experience of the Armenian diaspora through the long 20th century, from the role of the fin-de-siècle émigré Armenian press to the experience of Syrian-Armenian asylum seekers in the 21st century. It shows that a diaspora's statelessness can not only be evidence of its power, but also how this “stateless power” acts as an alternative and complement to the nation-state. Show less
During funerals of nobles in the Kuba kingdom (Democratic Republic of Congo), visitors used to theatrically offer so-called bongotols to the deceased and the mourning family. These highly... Show moreDuring funerals of nobles in the Kuba kingdom (Democratic Republic of Congo), visitors used to theatrically offer so-called bongotols to the deceased and the mourning family. These highly appreciated valuables were either positioned under the corpse to support it or displayed on top of it.In addition to their religious meanings they also displayed the status and wealth of both givers and takers. Visitors would receive similar items in return. Afterwards the bongotols were stashed until, on occasion of a next burial, they would continue their cycles of gift and counter gift among the titled Kuba aristocracy. Death and display brings ethnographic research and archival sources to bear on these intriguing heirlooms. Their rich iconography offers a kaleidoscope of traditional Kuba sociality, cosmology and ritual. Show less
The Renaissance Battle for Rome examines the rhetorical battle fought simultaneously between a wide variety of parties (individuals, groups, authorities) seeking prestige or legitimacy through the... Show moreThe Renaissance Battle for Rome examines the rhetorical battle fought simultaneously between a wide variety of parties (individuals, groups, authorities) seeking prestige or legitimacy through the legacy of ancient Rome—a battle over the question of whose claims to this legacy were most legitimate. Distinguishing four domains—power, morality, cityscape and literature—in which ancient Rome represented a particularly powerful example, this book traces the contours of this rhetorical battle across Renaissance Europe, based on a broad selection of Humanist Latin Poetry. It shows how humanist poets negotiated different claims on behalf of others and themselves in their work, acting both as "spin doctors" and "new Romans", while also undermining competing claims to this same idealized past. By so doing this book not only offers a new understanding of several aspects of the Renaissance that are usually considered separately, but ultimately allows us to understand Renaissance culture as a constant negotiation between appropriating and contesting the idea and ideal of "Rome." Show less
