Leiden University Scholarly Publications

Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma

Fc gamma RIIB regulates autoantibody responses by limiting marginal zone B cell activation

Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy

Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PL A2R1-associated membranous nephropathy

Long noncoding RNA H19X is a key mediator of TGF-beta-driven fibrosis

Cytotoxic CD4(+) T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization

Polymerase delta deficiency causes syndromic immunodeficiency with replicative stress

Chaperone protein HSC70 regulates intercellular transfer of Y chromosome antigen DBY

Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup

Inhibition of neogenin fosters resolution of inflammation and tissue regeneration

Mycobacterial growth inhibition is associated with trained innate immunity

Proteasome activity regulates CD8(+) T lymphocyte metabolism and fate specification

Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response

FOXP3(+) Tregs require WASP to restrain Th2-mediated food allergy

TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors

Therapeutic cancer vaccines

Helicobacter urease-induced activation of the TLR2/NLRP3/IL-18 axis protects against asthma

Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease

Calcium release channel RyR2 regulates insulin release and glucose homeostasis

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

Targeting development of incretin-producing cells increases insulin secretion