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Membrane lipid remodeling modulates γ-secretase processivity
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High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs
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Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits
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Transforming growth factor-beta challenge alters the N-, O-, and glycosphingolipid glycomes in PaTu-S pancreatic adenocarcinoma cells
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New insights into the type A glycan modification of Clostridioides difficile flagellar protein flagellin C by phosphoproteomics analysis
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Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells
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Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection
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Aspergillomarasmine A inhibits metallo-β-lactamases by selectively sequestering Zn2+
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Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET
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Human Gb3/CD77 synthase produces P1 glycotope-capped N-glycans, which mediate Shiga toxin 1 but not Shiga toxin 2 cell entry
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Molecular characterization of the RNA-protein complex directing-2/-1 programmed ribosomal frameshifting during arterivirus replicase expression
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An alternative model for type I interferon induction downstream of human TLR2
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An alternative model for type I interferon induction downstream of human TLR2
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C4b-binding protein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack (vol 282, pg 28540, 2007)
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Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents
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Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol
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Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription
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Gcn5 and Esa1 function as histone crotonyltransferases to regulate crotonylation-dependent transcription
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Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies
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Ega 3 from the fungal pathogen Asperfillus fumigatus is an endo-α-1,4-galactosaminidase that disrupts microbialbiofilms
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Molecular mechanisms of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases
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Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations
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Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family
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Nicotiana benthamiana α-galactosidase A1.1 can functionally complement human α-galactosidase A deficiency associated with Fabry disease
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