Leiden University Scholarly Publications

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: The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent

: Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV

: DUX4 expression in cancer induces a metastable early embryonic totipotent program

: QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations

: The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

: A single-cell level comparison of human inner ear organoids withthe human cochlea and vestibular organs

: Dimethyl itaconate induces long-term innate immune responses and confers protection against infection

: Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function

: Modulating mutational outcomes and improving precise gene editing at CRISPR-Cas9-induced breaks by chemical inhibition of end-joining pathways

: Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA

: Cancer-specific T helper shared and neo-epitopes uncovered by expression of the MHC class II master regulator CIITA

: mTORC1 signaling in antigen-presenting cells of the skin restrains CD8(+) T cell priming

: Cross-reactivity of glycan-reactive HIV-1 broadly neutralizing antibodies with parasite glycans

: Antibody bivalency improves antiviral efficacy by inhibiting virion release independently of Fc gamma receptors

: Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8(+) T cells

: RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair

: Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

: Physical interactions between MCM and Rad51 facilitate replication fork lesion bypass and ssDNA gap filling by non-recombinogenic functions

: Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5

: Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal

: Molecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation

: Global non-covalent SUMO interaction networks reveal SUMO-dependent stabilization of the non-homologous end joining complex

: The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

: Multistage signal-interactive nanoparticles improve tumor targeting through efficient nanoparticle-cell communications

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