Leiden University Scholarly Publications

Feasibility, safety, and efficacy of early prophylactic donor lymphocyte infusion after T cell-depleted allogeneic stem cell transplantation in acute leukemia patients

Predictors of short-term and long-term mortality in critically ill patients admitted to the intensive care unit following allogeneic stem cell transplantation

CMV seronegative donors: Effect on clinical severity of CMV infection and reconstitution of CMV-specific immunity

Effectivity of a strategy in elderly AML patients to reach allogeneic stem cell transplantation using intensive chemotherapy: Long-term survival is dependent on complete remission after first induction therapy

Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies

Host immunity dictates influenza A(H1N1)pdm09 infection outcome in hematology-oncology patients

Microarray gene expression analysis to evaluate cell type specific expression of targets relevant for immunotherapy of hematological malignancies

COMPARABLE SURVIVAL OF CRITICALLY ILL PATIENTS ADMITTED TO THE ICU FOLLOWING REDUCED INTENSITY AND MS ELOABLATIVE CONDITIONLNG ALLOGENEIC STEM CELL TRANSPLANTATION

Purified CD4 T-cell infusion can result in graft-versus-leukaemia without GVHD by recognition of broadly expressed minor histocompatibility antigens restricted by HLA class-II

HOVON 106: a phase II study to assess engraftment and engraftment kinetics after double cord blood transplantation preceded by a reduced-intensity conditioning regimen

Low incidence of viral complications after in vivo and in vitro T-cell depletion using low dose alemtuzumab is due to early post transplant outgrowth of protective virus specific CD4 and CD8 memory T-cells by various escape mechanisms

Rabbit-derived ATG but not horse-derived ATG in the conditioning induces a post transplant in vivo imbalance between B and T cell recovery resulting in high risk of EBV-associated PTLD

In Vivo T Cell Depletion Using Rabbit Derived ATG Leads to An Increased EBV-PTLD Risk Due to An Induced Imbalance Between B and T Cell Recovery Which Is Not Seen After Horse Derived ATG or Alemtuzumab

Long-Term Disease-Free Survival of Patients with AML Relapse After T-Cell-Depleted Allogeneic Stem Cell Transplantation by Re-Induction Therapy and Subsequent Interferon-Boosted Donor Lymphocyte Infusion

Post-Transplant Immune Suppressive Therapy Is Not Necessary In Related and Unrelated Reduced Intensity Conditioning Stem Cell Transplantation Using Low Dose Alemtuzumab In Vivo T Cell Depletion Combined with Alemtuzumab-Mediated In Vitro T Cell Depletion

Direct cloning of leukemia-reactive T cells from patients treated with donor lymphocyte infusions shows a relative dominance of hematopoiesis-restricted minor histocompatibility antigen HA-1 and HA-2 specific T cells.

Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia.

Multiple minor histocompatibility antigen disparities between a recipient and four HLA-identical potential sibling donors for bone marrow transplantation.

Minor histocompatibility antigen HA-1, -2, -4 and HY specific cytotoxic T cell clones inhibit human hematopoietic progenitor cell growth by a mechanism that is dependent on direct cell-cell contact.

Minor Histocompatibility antigen-specific cytotoxic T cell lines, capable of lysing human hematopoietic progenitor cells can be generated in vitro by stimulation with HLA-identical bone marrow cells.

Rejection of bone-marrow graft by recipient-derived cytotoxic T lymphocytes against minor histocompatibility antigens..