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DNA mismatch repair
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Lynch syndrome
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MSH6
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variants of uncertain significance
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Hees, S. van
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Wind, N. de
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Drost, M.
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Induction of mismatch repair deficiency, compromised DNA damage signaling and compound hypermutagenesis by a dietary mutagen in a cell-based model for Lynch syndrome
Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome
Excision of translesion synthesis errors orchestrates responses to helix-distorting DNA lesions
Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome
A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants
A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants