Leiden University Scholarly Publications

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: A pre-existing coordinated inflammatory microenvironment is associated with complete response of vulvar high-grade squamous intraepithelial lesions to different forms of immunotherapy

: Immunotherapeutic Potential of TGF-beta Inhibition and Oncolytic Viruses

: Strong vaccine responses during chemotherapy are associated with prolonged cancer survival

: Future challenges in cancer resistance to immunotherapy

: Tumor mutational load, CD8(+) T cells, expression of PD-L1 and HLA class I to guide immunotherapy decisions in NSCLC patients

: Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy

: Phase I/II study protocol to assess safety and efficacy of adoptive cell therapy with anti-PD-1 plus low-dose pegylated-interferon-alpha in patients with metastatic melanoma refractory to standard of care treatments: the ACTME trial

: Blood-based kinase activity profiling

: Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy

: Generation of TCR-engineered reference cell samples to control T-cell assay performance

: Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models

: Low-dose interferon-alpha preconditioning and adoptive cell therapy in patients with metastatic melanoma refractory to standard (immune) therapies

: CD163(+)cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer

: Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model

: Pre-existing inflammatory immune microenvironment predicts the clinical response of vulvar high-grade squamous intraepithelial lesions to therapeutic HPV16 vaccination

: Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4

: Targeting of the Cancer-Associated Fibroblast-T-Cell Axis in Solid Malignancies

: Long-term HPV-specific immune response after one versus two and three doses of bivalent HPV vaccination in Dutch girls

: Monalizumab: inhibiting the novel immune checkpoint NKG2A

: High numbers of activated helper T cells are associated with better clinical outcome in early stage vulvar cancer, irrespective of HPV or p53 status

: Tissue-Specific Gene Expression during Productive Human Papillomavirus 16 Infection of Cervical, Foreskin, and Tonsil Epithelium

: Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma

: Strong CD8+lymphocyte infiltration in combination with expression of HLA class I is associated with better tumor control in breast cancer patients treated with neoadjuvant chemotherapy

: Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types

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