Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the... Show moreCarbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci species. The synthesis of well-defined structures can allow an in-depth characterization of antigen-antibody binding that ultimately can help the development of robust and high effective vaccine. In the case of teichoic acids for example, it has been introduced the application of a microarray technology to streamline the preferential binding of immune proteins from different sources. The binding towards teichoic acids like structures has been further explore by developing a monoclonal antibody starting from a fully sinthetic glycoconjugate. Different techniques have been used which in conclusion suggest an indirect contribution of the glycosidic appandage to the binding towards the glycerol-phosphate backbone. Show less