Diseases and injuries related to bone and cartilage severely affect the function of the musculoskeletal system. They affect the life quality of patients and make them unable to move. The... Show moreDiseases and injuries related to bone and cartilage severely affect the function of the musculoskeletal system. They affect the life quality of patients and make them unable to move. The peculiarities of bone and cartilage structures mean that the therapeutic and surgical treatments that have been developed till date have a lot of disadvantages and limitations. Consequently, the development of new strategies for administering drugs that favor localized delivery is very important to achieve increasingly better treatments.The design and preparation of platforms for this purpose is a constant challenge, and for this reason three types of matrices were designed and prepared in the thesis. The drugs encapsulated in these matrices were cefazolin sodium, betamethasone, dexamethasone sodium phosphate, and Etanercept (anti-TNF-α drug). We were able to show that our matrices modified the release of the incorporated molecules and the composition of the prepared materials played an important role in the kinetics of the release process. Physicochemical characterizations were carried out on all the materials, obtaining that in each case the morphology varied once modifications in the matrix composition had been introduced. Biological studies in vitro and in vivo showed the cytocompatibility of the materials and also the ability to help repair damaged cartilage. Show less
Moussu, M.A.C.; Abdeddaim, R.; Dubois, M.; Georget, E.; Webb, A.G.; Nenasheva, E.; ... ; Enoch, S. 2022
Comments about the above article [1] were proposed. We thank and reply to the authors of the comments about our model of high-permittivity dielectric ring resonators used as microscopy magnetic... Show moreComments about the above article [1] were proposed. We thank and reply to the authors of the comments about our model of high-permittivity dielectric ring resonators used as microscopy magnetic resonance probes. In this prospect, we reply part by part to the comments. Show less
SDHD-related head and neck paragangliomas are, hereditary and generally benign, neuroendocrine tumors that arise from paraganglionic tissue associated with the parasympathetic nervous system.... Show moreSDHD-related head and neck paragangliomas are, hereditary and generally benign, neuroendocrine tumors that arise from paraganglionic tissue associated with the parasympathetic nervous system. The primary aim of this thesis was to gain more insight in the natural course of SDHD-related head and neck paragangliomas and ultimately improve surveillance and treatment strategies, as well as counseling of both patients and their family members. The risk of occult and metachronous paragangliomas, tumor growth, clinical progression and survival of SDHD germline mutation carriers were addressed. Show less
