Leiden University Scholarly Publications

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Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Muller Glia Are Targets of AAV5
Loss of CRB2 in Muller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype
CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function
The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy
Ablation of Crb2 Specifically in Mouse Photoreceptors with Crb1 loss in Muller Cells Mimics Leber Congenital Amaurosis
Ablation of Crb1 and Crb2 Specifically in Mouse Muller Cells mimics early onset Retinitis Pigmentosa
Gene therapy into photoreceptors and Muller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models
Targeted Ablation of Crb1 and Crb2 in Retinal Progenitor Cells Mimics Leber Congenital Amaurosis