We organized 10Kin1day, a pop-up scienti fi c event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000 + existing MRI connectivity datasets during a... Show moreWe organized 10Kin1day, a pop-up scienti fi c event with the goal to bring together neuroimaging groups from around the world to jointly analyze 10,000 + existing MRI connectivity datasets during a 3-day workshop. In this report, we describe the motivation and principles of 10Kin1day, together with a public release of 8,000 + MRI connectome maps of the human brain. Show less
Bos, D.J.; Oranje, B.; Achterberg, M.; Vlaskamp, C.; Ambrosino, S.; Reus, M.A. de; ... ; Durston, S. 2017
The human brain is a complex network of interconnected brain regions. In adulthood, the brain's network was recently found to be under genetic influence. However, the extent to which genes... Show moreThe human brain is a complex network of interconnected brain regions. In adulthood, the brain's network was recently found to be under genetic influence. However, the extent to which genes influence the functional brain network early in development is not yet known. We report on the heritability of functional brain efficiency during early brain development. Using a twin design, young children underwent resting-state functional magnetic resonance imaging brain scans (N=86 from 21MZ and 22DZ twin-pairs, age=12 years). Functional connectivity, defined as the temporal dependency of neuronal activation patterns of anatomically separated brain regions, was explored using graph theory and its heritability was examined using structural equation modeling. Our findings suggest that 'global efficiency of communication' among brain regions is under genetic control (h(2)lambda=42%), irrespectively of the total number of brain connections (connectivity density). In addition, no influence of genes or common environment to local clustering (gamma) was found, suggesting a less pronounced effect of genes on local information segregation. Thus our findings suggest that a set of genes is shaping the underlying architecture of functional brain communication during development. Show less
Bie, H.M.A. de; Oostrom, K.J.; Boersma, M.; Veltman, D.J.; Barkhof, F.; Delemarre-van de Waal, H.A.; Heuvel, M.P. van den 2011
