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Marciello, M.; Cusati, V.; Nicolosi, F.; Saavedra-Rubio, K.; Pierrat, E.; Thonemann, N.; Laurent, A. 2024

Evaluating the economic landscape of hybrid-electric regional aircraft: a cost analysis across three time horizons

Article / Letter to editor

under embargo until 2025-01-16

This article presents the results of a prospective cost analysis of future regional aviation solutions, specifically focusing on hybrid-electric regional aircraft for 50 passengers. The study spans three time horizons (short term, medium term, long term) and employs a validated workflow to estimate costs for various solutions, including conventional, hybrid-electric, and hydrogen-based architectures. A specialized cost model is introduced to assess the electric components of the powertrain, emphasizing maintenance expenses and energy costs. Despite the environmental promise of hybrid and electric solutions, the results reveal significantly higher direct operating costs (up to 69.8%) compared to conventional options. The study highlights the importance of targeted policies to incentivize sustainable alternatives, suggesting potential solutions such as discouraging kerosene-based aircraft and promoting sustainable aviation fuel. These insights provide valuable guidance for industry stakeholders navigating the path toward a more sustainable and economically viable aviation future.

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Creutzig, F.; Simoes, S. G.; Leipold, S.; Berrill, P.; Azevedo, I.; Edelenbosch, O.; ... ; Wilson, C. 2024

Demand-side strategies key for mitigating material impacts of energy transitions

Article / Letter to editor

under embargo until 2025-01-05

As fossil fuels are phased out in favour of renewable energy, electric cars and other low-carbon technologies, the future clean energy system is likely to require less overall mining than the... Show moreAs fossil fuels are phased out in favour of renewable energy, electric cars and other low-carbon technologies, the future clean energy system is likely to require less overall mining than the current fossil-fuelled system. However, material extraction and waste flows, new infrastructure development, land-use change, and the provision of new types of goods and services associated with decarbonization will produce social and environmental pressures at localized to regional scales. Demand-side solutions can achieve the important outcome of reducing both the scale of the climate challenge and material resource requirements. Interdisciplinary systems modelling and analysis are needed to identify opportunities and trade-offs for demand-led mitigation strategies that explicitly consider planetary boundaries associated with Earth’s material resources. Show less

Veer, C.B. van 't 2024

De gedenkschriften van poes Polly en hond Jack: dierautobiografieën in de Indische jeugdliteratuur

Article / Letter to editor

under embargo until 2025-05-15

Gregorio, C.; Spreafico, M.; D'Amico, S.; Sauta, E.; Asti, G.; Lanino, L.; ... ; Ieva F. 2024

Personalized timing for allogeneic stem-cell transplantation in hematologic neoplasms: a target trial emulation approach using multistate modeling and microsimulation

Article / Letter to editor

under embargo until 2024-11-10

Velzen, M. van; Boru, A.; Sarton, E.; Beaufort, A.J. de 2024

Design thinking in medical education to tackle real world healthcare problems: The MasterMinds Challenge

Article / Letter to editor

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Kazilas, C.; Dufresnes, C.; France, J.M.; Kalaentzis, K.; Martínez-Solano, I.; Visser, M.C. de; ... ; Wielstra, B.M. 2024

Spatial genetic structure in European marbled newts revealed with target enrichment by sequence capture

Article / Letter to editor

under embargo until 2024-11-02

Saxena, A.; Fletcher, G.; Pechenizkiy, M. 2024

FairSNA: algorithmic fairness in Social Network Analysis

Article / Letter to editor

under embargo until 2024-10-27

Schaftenaar, F.H.; Dam, A.D. van; Bruin, G. de; Depuydt, M.A.C.; Mol, J.; Amersfoort, J.; ... ; Kuiper, J. 2024

Immunoproteasomal inhibition with ONX-0914 attenuates atherosclerosis and reduces white adipose tissue mass and metabolic syndrome in mice

Article / Letter to editor

under embargo until 2024-10-26

Atherosclerosis is the major underlying pathology of cardiovascular disease and is driven by dyslipidemia and inflammation. Inhibition of the immunoproteasome, a proteasome variant that is... Show moreAtherosclerosis is the major underlying pathology of cardiovascular disease and is driven by dyslipidemia and inflammation. Inhibition of the immunoproteasome, a proteasome variant that is predominantly expressed by immune cells and plays an important role in antigen presentation, has been shown to have immunosuppressive effects.We assessed the effect of ONX-0914, an inhibitor of the immunoproteasomal catalytic subunits LMP7 (proteasome subunit β5i/large multifunctional peptidase 7) and LMP2 (proteasome subunit β1i/large multifunctional peptidase 2), on atherosclerosis and metabolism in LDLr-/- and APOE*3-Leiden.CETP mice.ONX-0914 treatment significantly reduced atherosclerosis, reduced dendritic cell and macrophage levels and their activation, as well as the levels of antigen-experienced T cells during early plaque formation, and Th1 cells in advanced atherosclerosis in young and aged mice in various immune compartments. Additionally, ONX-0914 treatment led to a strong reduction in white adipose tissue mass and adipocyte progenitors, which coincided with neutrophil and macrophage accumulation in white adipose tissue. ONX-0914 reduced intestinal triglyceride uptake and gastric emptying, likely contributing to the reduction in white adipose tissue mass, as ONX-0914 did not increase energy expenditure or reduce total food intake. Concomitant with the reduction in white adipose tissue mass upon ONX-0914 treatment, we observed improvements in markers of metabolic syndrome, including lowered plasma triglyceride levels, insulin levels, and fasting blood glucose.We propose that immunoproteasomal inhibition reduces 3 major causes underlying cardiovascular disease, dyslipidemia, metabolic syndrome, and inflammation and is a new target in drug development for atherosclerosis treatment. Show less

Uijterwaal, M.H.; Dijk, D. van; Lok, C.A.R.; Kroon, C.D. de; Kasius, J.C.; Zweemer, R.; ... ; Nooij, L.S. 2024

Prognostic value of molecular classification in stage IV endometrial cancer

Article / Letter to editor

under embargo until 2024-10-23

Objectives Multiple studies have proven the prognostic value of molecular classification for stage I–III endometrial cancer patients. However, studies on the relevance of molecular classification... Show moreObjectives Multiple studies have proven the prognostic value of molecular classification for stage I–III endometrial cancer patients. However, studies on the relevance of molecular classification for stage IV endometrial cancer patients are lacking. Hypothetically, poor prognostic molecular subtypes are more common in higher stages of endometrial cancer. Considering the poor prognosis of stage IV endometrial cancer patients, it is questionable whether molecular classification has additional prognostic value. Therefore, we determined which molecular subclasses are found in stage IV endometrial cancer and if there is a correlation with progression-free and overall survival.Methods A retrospective multicenter cohort study was conducted using data from five Dutch hospitals. Patients with stage IV endometrial cancer at diagnosis who were treated with primary cytoreductive surgery or cytoreductive surgery after induction chemotherapy between January 2000 and December 2018 were included. Exclusion criteria were age <18 years or recurrent disease. The molecular classification was performed centrally on all tumor samples according to the World Health Organization 2020 classification (including POLE and estrogen receptor status). The Kaplan–Meier method was used to calculate progression free and overall survival in the molecular subclasses, for the different histological subtypes and for estrogen receptor positive versus estrogen receptor negative tumors. Groups were compared using the log-rank test.Results 164 stage IV endometrial cancer patients were molecularly classified. Median age of the patients was 67 years (range 33–86). Most patients presented with a non-endometrioid histological subtype (58%). Intra-abdominal complete cytoreductive surgery was achieved in 60.4% of the patients. 101 tumors (61.6%) were classified as p53 abnormal, 35 (21.3%) as no specific molecular profile, 21 (12.8%) as mismatch repair deficient, and 6 (3%) as POLE mutated. Molecular classification had no significant impact on progression free (p=0.056) or overall survival (p=0.12) after cytoreductive surgery. Overall survival was affected by histologic subtype (p<0.0001) and estrogen receptor status (p=0.013).Conclusion The distribution of the molecular subclasses in stage IV endometrial cancer patients differed substantially from the distribution in stage I–III endometrial cancer patients, with the unfavorable subclasses being more frequently present. Although the molecular classification was not prognostic in stage IV endometrial cancer, it could guide adjuvant treatment decisions. Show less

Yenkimaleki, M.; Heuven, V.J.J.P. van 2024

The effect of fluency training on interpreter trainees’ speech fluency, comprehensibility, and accentedness: an experimental study

Article / Letter to editor

under embargo until 2024-10-02

Fluency, comprehensibility, and accentedness are considered importantparameters of interpreting quality but have rarely been studiedsystematically in training programs of interpreting. Therefore,... Show moreFluency, comprehensibility, and accentedness are considered importantparameters of interpreting quality but have rarely been studiedsystematically in training programs of interpreting. Therefore, the presentstudy was set up to investigate the effect of fluency training on speechfluency, comprehensibility, and accentedness of interpreter trainees. Twogroups of interpreter trainees at a university in Iran took part in the study,receiving the same amount of instruction and practice (12 hours over 4weeks). The experimental group (N=30) spent 33% of the time (i.e., 4 of the12 hours in the training program) on dedicated fluency strategy training,encouraging the memorization, repetition, and retelling of audio and videomaterials. The remaining 67% was spent on training general speaking skills.The control group (N=30) were only taught general speaking skills in thetraining program but received no dedicated fluency training. Systematicinterviews were run to assess the interpreter trainees’ speech fluency,comprehensibility and accentedness, which were judged independently bythree expert raters at three moments of testing, i.e., pretest, immediateposttest, and delayed posttest (one month later). The findings revealed thatthe fluency training significantly enhanced the interpreter trainees’ fluency,and to a lesser extent the students’ comprehensibility but had only amarginal effect on accentedness. The pedagogical implication would be thatawareness training on speech fluency Show less

Veal, C.; Tomlinson, A.; Cipriani, A.; Bulteau, S.; Henry, C.; Müh, C.; ... ; Chevance, A. 2024

Heterogeneity of outcome measures in depression trials and the relevance of the content of outcome measures to patients: a systematic review

Article / Letter to editor

under embargo until 2024-10-01

Hasan-Aslih, S.; Pliskin, R.; Shuman, E.; Zomeren, M. van; Saguy, T.; Halperin, E. 2024

Together we will rise? Perceptions of instrumentality and normalization as motivations for joint collective action among the disadvantaged

Article / Letter to editor

under embargo until 2025-07-19

The current research examines joint collective action between advantaged and disadvantaged groups, from the perspective of the latter. We hypothesize that joint action poses a dilemma which lies in... Show moreThe current research examines joint collective action between advantaged and disadvantaged groups, from the perspective of the latter. We hypothesize that joint action poses a dilemma which lies in the tension between perceived instrumentality of joint action (i.e., ability to promote the disadvantaged’s goals) and perceived normalization (i.e., its tendency to blur power relations). We test this idea across three studies in the United States and Israel/Palestine. In Study 1 (n = 361) we manipulated perceptions of joint action from the perspective of a hypothetical character, and in Study 2 (n = 378) we presented participants with an article highlighting the risk and benefit of joint activism. Results showed that perceived instrumentality increases, whereas perceived normalization decreases joint action tendencies. In Study 3 (n = 240), we described a joint action event that taps into some of the themes that induce concerns about normalization. We found that normalization perceptions feed into perceptions of instrumentality, and this occurred mainly among high identifiers, for whom the dilemma is most salient. The implications of these findings for understanding the complexity of joint collective action from the perspective of the disadvantaged are discussed. Show less

Hoenig, L.C.; Pliskin, R.; Dreu, C.K.W. de 2024

Equality and efficiency shape cooperation in multiple-public-goods provision problems

Article / Letter to editor

under embargo until 2024-10-05

The functioning of groups and societies requires that individuals cooperate on public goods such as healthcare and state defense. More often than not, individuals face multiple public goods and... Show moreThe functioning of groups and societies requires that individuals cooperate on public goods such as healthcare and state defense. More often than not, individuals face multiple public goods and must choose on which to cooperate, if at all. Such decisions can be difficult when public goods are attractive on one dimension (e.g., being “efficient” in providing comparatively high returns) and unattractive on another (e.g., creating inequality by providing some group members greater returns than others). We examined how people manage such decision conflicts in five preregistered experiments (N = 900) that confronted participants with two public goods that varied in efficiency and (in)equality of returns. People cooperated more on the comparatively efficient public good and on the equal-return (vs. unequal-return) public good (Experiment 1), yet when the unequal-returns public good was also the most efficient, individuals cooperated comparatively more on this unequal-but-efficient public good when they themselves benefitted the most from inequality (Experiments 2–4). Low beneficiaries largely ignored public goods efficiency and preferentially cooperated on the equal- rather than unequal-returns public good. Expectations (Experiments 2–4), preferences for revising the multiple-public-goods provision problems’ choice architecture (Experiments 3–4), and descriptive norms held by uninvolved arbitrators (Experiment 5) echoed these cooperation patterns, but uninvolved arbitrators deemed it socially appropriate to cooperate more on the equal than the unequal public good regardless of beneficiary position. We discuss implications for theory and policy on cooperation Show less

Krijger, T.E.M. 2024

Protestants activisme en het Nederlandse archiefwezen: de “verzuiling” werkt nogal altijd door

Article / Letter to editor

under embargo until 2024-09-30

Pérez-Chada, L.M.; Hopkins, Z.H.; Balak, D.M.W.; Rashid, S.; Creadore, A.; Chu, B.; ... ; Barbieri, J.S. 2024

Patient-reported outcome measures for health-related quality of life in patients with psoriasis: a systematic review

Article / Letter to editor

under embargo until 2024-06-30

Importance Multiple patient-reported outcome measures (PROMs) for health-related quality of life (HRQL) exist for patients with psoriasis. Evidence for the content validity and other measurement... Show moreImportance Multiple patient-reported outcome measures (PROMs) for health-related quality of life (HRQL) exist for patients with psoriasis. Evidence for the content validity and other measurement properties of these PROMs is critical to determine which HRQL PROMs could be recommended for use.Objective To systematically review the validity of HRQL-focused PROMs used in patients with psoriasis.Evidence Review Using PubMed and Embase, full-text articles published in English or Spanish on development or validation studies for psoriasis-specific, dermatology-specific, or generic HRQL PROMs were included. Development studies included original development studies, even if not studied in psoriasis patients per Consensus-Based Standards for the Selection of Health Measurement Instruments (COSMIN) recommendations. If a study included multiple diagnoses, more than 50% of patients had to have psoriasis or psoriasis-specific subgroup analyses available. Data extraction and analysis followed the COSMIN guidelines. Two independent reviewers extracted and analyzed the data, including PROM characteristics, quality of measurement properties (structural validity, internal consistency, cross-cultural validity, reliability, measurement error, criterion validity, construct validity, and responsiveness), and level of evidence. PROMs were classified into 3 levels of recommendations: (1) PROM recommended for use; (2) PROM requires further validation; and (3) PROM not recommended for use.Findings Overall, 97 articles were identified for extraction. This included 19 psoriasis-specific, 8 skin-specific, and 6 generic PROMs. According to COSMIN standards, most measures identified received a B recommendation for use, indicating their potential but requiring further validation. Only the Rasch reduced version of the Impact of Psoriasis Questionnaire (IPSO-11 Rasch) received an A recommendation for use given that it had sufficient content validity, structural validity, and internal consistency.Conclusions and Relevance This study identified a significant lack of information concerning the quality of HRQL measures in psoriasis. This gap in knowledge can be attributed to the fact that traditional measures were developed using validation criteria that differ from the current standards in use. Consequently, additional validation studies in accordance with contemporary standards will be useful in aiding researchers and clinicians in determining the most suitable measure for assessing HRQL in patients with psoriasis. Show less

Wijk, E.V. van; Blankenstein, F.M. van; Donkers, J.; Janse, R.J.; Bustraan, J.; Adelmeijer, L.G.M.; ... ; Langers, A.M.J. 2024

Does 'summative' count? The influence of the awarding of study credits on feedback use and test-taking motivation in medical progress testing

Article / Letter to editor

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Crijns, J.H.; Dubelaar, M.J. 2024

Rubriek straf(proces)recht

Article / Letter to editor

under embargo until 2024-09-11

Wijk, E.V. van; Blankenstein, F.M. van; Janse, R.J.; Dubois, E.A.; Langers, A.M.J. 2024

Understanding students' feedback use in medical progress testing: A qualitative interview study

Article / Letter to editor

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BackgroundActive engagement with feedback is crucial for feedback to be effective and improve students' learning and achievement. Medical students are provided feedback on their development in the... Show moreBackgroundActive engagement with feedback is crucial for feedback to be effective and improve students' learning and achievement. Medical students are provided feedback on their development in the progress test (PT), which has been implemented in various medical curricula, although its format, integration and feedback differ across institutions. Existing research on engagement with feedback in the context of PT is not sufficient to make a definitive judgement on what works and which barriers exist. Therefore, we conducted an interview study to explore students' feedback use in medical progress testing.MethodsAll Dutch medical students participate in a national, curriculum-independent PT four times a year. This mandatory test, composed of multiple-choice questions, provides students with written feedback on their scores. Furthermore, an answer key is available to review their answers. Semi-structured interviews were conducted with 21 preclinical and clinical medical students who participated in the PT. Template analysis was performed on the qualitative data using a priori themes based on previous research on feedback use.ResultsTemplate analysis revealed that students faced challenges in crucial internal psychological processes that impact feedback use, including 'awareness', 'cognizance', 'agency' and 'volition'. Factors such as stakes, available time, feedback timing and feedback presentation contributed to these difficulties, ultimately hindering feedback use. Notably, feedback engagement was higher during clinical rotations, and students were interested in the feedback when seeking insights into their performance level and career perspectives.ConclusionOur study enhanced the understanding of students' feedback utilisation in medical progress testing by identifying key processes and factors that impact feedback use. By recognising and addressing barriers in feedback use, we can improve both student and teacher feedback literacy, thereby transforming the PT into a more valuable learning tool. Show less

Barkhuysen, T. 2024

Waait er een nieuwe wind in handhavingsland?

Article / Letter to editor

under embargo until 2024-09-08

Masson, T.L. 2024

Hoe staat het met de regulering van ruimtemijnbouw? Een update

Article / Letter to editor

under embargo until 2024-09-01

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