Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of... Show moreSpectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral lines’ position can be observed in response to weak variations in local fields. These variations can for instance be caused by rearrangements of charges or minute changes in the crystal lattice around the molecule. Therefore, molecules are sensitive sensors to what happens at the nanoscale. This is exemplified by coupling to an external electric field, inducing a Stark shift of the molecule’s spectral lines, as shown in Chapter 4. Other dynamics, related to the crystal around the molecule, are resolved in the fluorescence of molecules on the surface of two-dimensional hexagonal boron nitride, shown in Chapter 5. In Chapter 2, 3 and 6, perylene molecules are studied in a new host crystal with the aim of detecting a ‘forbidden’ transition to the triplet state from the ground state, a transition required for building a single-molecule optical switch. Show less
In this thesis we study curves. In the first half, we study moduli spaces of curves and Gromov-Witten invariants, certain kinds of curves counts. We employ logarithmic geometry for this. Some major... Show moreIn this thesis we study curves. In the first half, we study moduli spaces of curves and Gromov-Witten invariants, certain kinds of curves counts. We employ logarithmic geometry for this. Some major results include the polynomiality of the double ramification cycle and recursive relations for the log double ramification cycle.In the second half we study rational points on curves, in particular Chabauty's method for finding the rational points and extensions of it. Major results include that the geometric (quadratic) Chabauty method is theoretically stronger than the original (quadratic) Chabauty method, and that local heights for quadratic Chabauty are explicitly computable. Show less
The research developed in this doctoral dissertation contributes to Sasanian studies in particular, and to ancient Iranian studies more generally, in three main ways. First, it offers a critical... Show moreThe research developed in this doctoral dissertation contributes to Sasanian studies in particular, and to ancient Iranian studies more generally, in three main ways. First, it offers a critical study of the history of research surrounding the decipherment of the Middle Persian script, to define the contribution of Sasanian epigraphy to the broader historiographical debates concerning the study of Late Antiquity. Then, through the palaeographic analysis of the earliest pre-Sasanian and Sasanian Middle Persian written vestiges, it highlights the existence of a lively scribal tradition that was local to Persis in the Seleucid and Parthian periods. Finally, it investigates a possible model for the study of Sasanian inscriptions which takes into account the references made in these monumental texts to (now lost) manuscript documents, as well as to key features of their natural and built environment; this helps bring into sharp focus the often overlooked legal, administrative and religious functions of Sasanian rock-cut texts. Show less
The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power... Show moreThe marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing. In contrast, the pollution impact of maritime transport continues to increase. This generates a big societal pressure, resulting in regulations proposed by the International Maritime Organization (IMO). These regulations impose restrictions on emission levels from ships. While various methods are used to assess the emission from ships in ports and off-coastal areas, monitoring over the open sea has been infeasible. The game-changer is the TROPOMI instrument on board the Sentinel 5 Precursor Satellite – studies show that NO2 plumes from some individual seagoing ships can be distinguished on TROPOMI images. The objective of this thesis is to pave the way toward the application of the TROPOMI instrument for the monitoring of compliance of seagoing ships. This is achieved through the fusion of machine learning, feature engineering, and data integration. Each chapter builds upon the findings of its predecessor, as a whole, representing state-of-the-art knowledge in the application of TROPOMI data for the monitoring of NO2 emissions from individual seagoing ships. Show less
What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for... Show moreWhat physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted all traditional methods of understanding. It calls for a complete change in paradigm. An unexpected venue for progress was found in the study of gravity. By studying special gravitational solutions such as black holes and stars made of electrons, it turns out to be possible to shed some light on the physics and transport properties of quantum matter. This analysis relies on the use of high-performance computations to obtain these gravitational solutions, but the payoff is access to uncharted areas of physics. So far, such methods have successfully brought some insight into the flow of energy in such systems, but the flow of electric charge or the quantum information patterns remain shrouded in mystery. The findings of this thesis address key parts of these questions, particularly in the context of black holes as models of exotic quantum metals. Show less
To test the hypothesis that early-life adversity accelerates the pace of biological aging, we analyzed data from the Dutch Hunger Winter Families Study (DHWFS, N = 951). DHWFS is a natural... Show moreTo test the hypothesis that early-life adversity accelerates the pace of biological aging, we analyzed data from the Dutch Hunger Winter Families Study (DHWFS, N = 951). DHWFS is a natural-experiment birth-cohort study of survivors of in-utero exposure to famine conditions caused by the German occupation of the Western Netherlands in Winter 1944 to 1945, matched controls, and their siblings. We conducted DNA methylation analysis of blood samples collected when the survivors were aged 58 to quantify biological aging using the DunedinPACE, GrimAge, and PhenoAge epigenetic clocks. Famine survivors had faster DunedinPACE, as compared with controls. This effect was strongest among women. Results were similar for GrimAge, although effect-sizes were smaller. We observed no differences in PhenoAge between survivors and controls. Famine effects were not accounted for by blood-cell composition and were similar for individuals exposed early and later in gestation. Findings suggest in-utero undernutrition may accelerate biological aging in later life. Show less
More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely... Show moreMore than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary. We have now moved into the era of exoplanet atmospheric characterisation. Two crucial techniques for characterizing these exoplanets from the ground are high-contrast imaging and high-resolution spectroscopy. In the first part of the thesis, existing facilities are used to characterize the atmospheres of two of the most accessible types of planets: An ultra-hot Jupiter (WASP-76b) and a young supter-Jupiter (beta Pictoris b). The second part of the thesis develops instrumental concepts that are required to push exoplanet characterization towards smaller and closer-in planets. It shows how we can choose between spectral resolution, bandwidth, and field-of-view in developing an instrument for exoplanet detection, and how one can design an nearly optimal wavefront sensor for adaptive optics. Finally, it is demonstrated how machine learning techniques can help us improve the performance of these adaptive optics systems such that we can reach deeper contrasts for exoplanet imaging and characterization. Show less
In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and... Show moreIn this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains in computationally demanding imaging applications. Chapter 2 concerns the implementation of real-time segmentation of X-ray computed tomography (CT). Chapter 3 concerns the end-to-end optimization of various CT workflows by using auto-differentiation frameworks. Chapter 4 concerns a novel pruning method for neural network to significantly increase the speed of convolutional neural networks (CNNs). Chapter 5 comprises a benchmark study of optimization algorithms for tuning GPU kernels, and introduces a novel graph-based approach to quantify search space difficulty. Chapter 6 introduces a novel model to improve the energy efficiency of GPUs. Show less
The aim of this thesis was to gain a better understanding of the deleterious effects of Neonatal Brachial Plexus Palsy (NBPP) on central development by analyzing sensory and motor function.The... Show moreThe aim of this thesis was to gain a better understanding of the deleterious effects of Neonatal Brachial Plexus Palsy (NBPP) on central development by analyzing sensory and motor function.The explanation for problems with hand function was not clear in children who had an upper NBPP where only the C5 and C6 spinal nerves are affected, which predominantly innervate the shoulder and elbow flexion. The main findings of this thesis: Children with an upper NBPP have a diminished sensibility of the thumb and index finger which correlates with diminished dexterity. The ability to localize stimuli to the thumb, index, third and fourth fingers is disturbed in children with an upper NBPP. Most children with an upper NBPP are not aware of the diminished sensibility in their affected hand. Also Grip force of the hand is reduced in children with an upper NBPP lesion. NBPP is a peripheral nervous lesion, which affects the development of the central nervous system as well. The age at which children with NBPP can walk independently is delayed, which does not depend on the severity of the lesion. Treatment of children with a NBPP had to focus on the total development of the child. Show less
Gestel, L.C. van; Adriaanse, M.A.; Kanis, S.L.; Mensink-Bout, S.M.; Schoones, J.W.; Numans, M.E.; ... ; Brink, G. van den 2024
Background Proton Pump Inhibitors (PPI) are frequently prescribed. Long-term use is associated with side-efects and patients often lack a valid indication. Inappropriate PPI prescribing thus needs... Show moreBackground Proton Pump Inhibitors (PPI) are frequently prescribed. Long-term use is associated with side-efects and patients often lack a valid indication. Inappropriate PPI prescribing thus needs to be addressed. This review aims to scope 1) what determinants are studied as reasons for PPI prescribing, 2) what strategies are used for changing PPI (de)prescribing, and 3) whether important determinants are addressed in these interventions. Methods We searched eight databases for papers on determinants of physician PPI prescribing. Studies were included if they were conducted in a Western country and focused on oral PPIs for an adult population. By follow‑ ing the Behaviour Change Wheel, we extracted information regarding PPI prescribing behavior, behavioral determi‑ nants and intervention strategies. Findings We included 74 papers. Most focused on the determinants knowledge and beliefs about consequences. The latter was consistently related to PPI prescribing. Results for knowledge were mixed. Most interventions used education or enablement (e.g., algorithms, quality check improvements, involvement of pharmacists) as strategies. Enablement consistently improved PPI prescribing, while results for education were mixed. Interpretation There is an overemphasis on refective processes in studies on PPI prescribing. Future research should comprehensively identify behavioral determinants, focusing on refective and impulsive processes, such that interven‑ tions can address the most important determinants. Show less
ObjectiveTo evaluate the effectiveness of long-term, personalized, supervised exercise therapy on functional ability compared with usual care in people with axial spondyloarthritis (axSpA) and... Show moreObjectiveTo evaluate the effectiveness of long-term, personalized, supervised exercise therapy on functional ability compared with usual care in people with axial spondyloarthritis (axSpA) and severe functional limitations.MethodsParticipants were randomly 1:1 assigned to the intervention [maximal 64 sessions, with 14 additional optional sessions of supervised active exercise therapy (e.g. aerobic and muscle strengthening) with individualized goal-setting, education and self-management regarding physical activity] or usual care (care determined by clinician(s) and participants themselves). Primary endpoint was the change in the Patient-Specific Complaints activity ranked 1 [PSC1 (0–10)] at 52 weeks. Secondary endpoints were the PSC activities ranked 2 and 3, the Bath Ankylosing Spondylitis Functional Index, 6-min walk test, Patient Reported Outcome Measurement Information System-Physical Function-10 and the Short Form-36 Physical and Mental Component Summary Score (SF-36 PCS and MCS). Statistical comparisons comprised independent student t-tests and linear mixed models, based on intention-to-treat.Results214 participants [49% female, age 52 (S.D. 12) years], were randomized to the intervention (n = 110) or usual care (n = 104) group. In the intervention group 93% started treatment, using on average 40.5 sessions (S.D. 15.1). At 52 weeks, the difference in change in PSC1 between groups favoured the intervention group [mean difference (95% CI); −1.8 (−2.4 to −1.2)]. Additionally, all secondary outcomes, except the SF-36 MSC, showed significantly greater improvements in the intervention group with effect sizes ranging from 0.4 to 0.7.ConclusionLong-term, supervised exercise therapy proved more effective than usual care in improving functional disability and physical quality of life in people with axSpA and severe functional limitations.Trial registrationNetherlands Trial Register NL8238, included in the International Clinical Trial Registry Platform (ICTRP) (https://trialsearch.who.int/Trial2.aspx?TrialID=NL8238). Show less
The mid-sixteenth century was a time of rapidly intensifying interest in the study of living nature. Networks of experts described a rapidly growing number of species, complementing descriptions... Show moreThe mid-sixteenth century was a time of rapidly intensifying interest in the study of living nature. Networks of experts described a rapidly growing number of species, complementing descriptions with ad vivum depictions. Since the increase in the number of known species soon called for an organisation of this information, to keep this accessible and navigable, naturalists experimented with classifications and the presentation of information in text and image. This dissertation explores questions about the management of knowledge and information specifically in the context of natural history, looking at a subfield of zoology, the study of fishes and other aquatic animals, as an example, taking as a point of departure the works published by the naturalist Conrad Gessner (1516-1565). Gessner aimed to incorporate into his works an overview of the state of knowledge. As a result his work presents an ideal case study from which to approach questions such as: What happens when a field of knowledge experiences a sudden influx of information? How is information made accessible, how do researchers keep the overview of an increasing quantity of information? How is rudimentary and incomplete information processed and presented, how does it affect established interpretations and methods of working? Show less
Political theological explorations of the international have mounted an important challenge to standard secularization narratives by drawing attention to the manner in which modern international... Show morePolitical theological explorations of the international have mounted an important challenge to standard secularization narratives by drawing attention to the manner in which modern international political thought has taken up and refashioned theological notions. However, there exists a certain danger of reducing the political theological move to the level of intellectualism. Explorations would benefit from attention to theology understood as an embodied form of understanding, as a way of life, and more specifically to the manner in which desire shapes understanding of and action within the world of international politics. This chapter details the intellectualist danger in two prominent, recent interjections regarding the political theology of the international, those of Seán Molloy and William Bain. Next it flags how two key critics of the political theological move, Mark Lilla and Hans Blumenberg, actually recognize the centrality of desire in human thought and action, while also noting the inadequacies of their accounts. It then highlights how the work of Charles Taylor and Talal Asad might inspire a political theology of the international that avoids the intellectualist danger by giving attention to desire. Show less
International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental... Show moreInternational trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring. This dissertation explores the role of international trade on the environmental impacts of two sectors: the food system and the plastic waste system. For each system, this work finds that international trade leads to unwelcomed tradeoffs. Within the food system, in the form of consumption patterns that have been able to shift towards more land intensive diets. Adopting more autarkic food policies may help shift food consumption back towards diets that are more in line with planetary boundaries while also improving the efficiency of currently underdeveloped food supply chains. Within the plastic waste system, international trade has been detrimental by increasing plastic waste leaking to the aquatic environment, particularly from high-income countries. Recycling policies within these countries have amplified the quantities of plastic waste being exported to reach recycling metrics, ultimately highlighting the need for improved metrics to evaluate the environmental tradeoffs of plastic waste disposal. Show less
Grewal, S.; Theijse, R.T.; Dunlop, G.; Deurzen, D.F.P. van; Bekerom, M.P.J. van den; Klautz, R.J.M.; ... ; Grewal, N. 2024
Background: Professional athletes navigate a multitude of unique challenges associated to sport-specific factors (e.g., training, travel and competition) and non-sport factors (e.g., performance... Show moreBackground: Professional athletes navigate a multitude of unique challenges associated to sport-specific factors (e.g., training, travel and competition) and non-sport factors (e.g., performance pressure, stress and anxiety) that can interfere with healthy sleep behaviors. Sleep plays a key role in proper biopsychosocial development as well as short- and long-term biological, physical, psychological, and cognitive health. As poor sleep quality is known to impair proper brain function, this study aimed to investigate the effect of sleep quality on a professional athlete's ability to train, recover, and perform, as well as their overall emotional and physical well-being. Methods: A cohort study was performed in 40 professional male cricket athletes from the Dutch national cricket team (mean age 26.5 ± 5.1 years). The athletes were monitored across a 22 weeks in-season training period. Sleep quality and overall emotional and physical well-being were assessed using daily sleep diaries and questionnaires which scored the readiness to train, stress levels, fatigue, muscle soreness and flu symptoms respectively. Quality of sleep and subsequent association with the consecutive elements of the well-being questionnaire were assessed through statistical using the student t-test and clinical differences with the methodology of Osoba and colleagues: 20% “very much change”. Results: The results demonstrated that the professional athletes assessed their sleep quality as average with a mean score of 3.4 out of 5. Lower perceived quality of sleep (<75th percentile) was correlated with a decreased readiness to train (mean score 3.2 [IQR: 3.0–4.0] vs. 3.5 [IQR: 3.0–5.0]; P < 0.001) and increased extent of muscle soreness (2.7 [IQR: 2.0–3.0] vs. 2.3 [IQR: 2–3]; P < 0.001), stress level (mean score 2.3 [IQR: 2.0–3.0] vs. 1.9 [IQR: 1.0–2.0]; P < 0.001) and perceived fatigue (mean score 2.9 [IQR: 2.0–3.0] vs. 2.3 [IQR: 2.0–3.0]; P < 0.001). Likewise, in patients with lower perceived quality of sleep, the proportion of players presenting with flu symptoms increased over 4-fold (4.1% vs. 17%; P < 0.001). Show less