Low-Density Lipoprotein Receptor-Dependent and Low-Density Lipoprotein Receptor-Independent Mechanisms of Cyclosporin A-Induced Dyslipidemia

Kockx, M.; Glaros, E.; Leung, B.; Ng, T.W.; Berbee, J.F.P.; Deswaerte, V.; ... ; Kritharides, L. (2016)

Article / Letter to editor

Conclusions-We demonstrate that CsA does not cause hyperlipidemia via direct effects on the LDLr. Rather, LDLr deficiency plays an important permissive role for CsA-induced hyperlipidemia, which is associated with abnormal lipoprotein clearance, decreased lipoprotein lipase activity, and increased levels of apolipoprotein C-III and proprotein convertase subtilisin/kexin type 9. Enhancing LDLr and lipoprotein lipase activity and decreasing apolipoprotein C-III and proprotein convertase subtilisin/kexin type 9 levels may therefore provide attractive treatment targets for patients with hyperlipidemia receiving CsA.

• apolipoprotein C-III
• cyclosporin A
• hyperlipidemia
• immunosuppression
• lipolysis
• proprotein convertase subtilisin/kexin type 9
• triglycerides

• All authors: Kockx, M.; Glaros, E.; Leung, B.; Ng, T.W.; Berbee, J.F.P.; Deswaerte, V.; Nawara, D.; Quinn, C.; Rye, K.A.; Jessup, W.; Rensen, P.C.N.; Meikle, P.J.; Kritharides, L.
• Date: 2016-06-01
• Journal: Arteriosclerosis, Thrombosis, and Vascular Biology
• Volume: 36
• Issue: 7
• Pages: 1338 - +
• DOI: doi:10.1161/ATVBAHA.115.307030