Energy restriction and Roux-en-Y gastric bypass reduce postprandial alpha-dicarbonyl stress in obese women with type 2 diabetes

Maessen, D.E.; Hanssen, N.M.; Lips, M.A.; Scheijen, J.L.; Dijk, K.W. van; Pijl, H.; ... ; Schalkwijk, C.G. (2016)

Article / Letter to editor

Conclusions/interpretation This study shows that type 2 diabetes is characterised by increased fasting and postprandial plasma alpha-dicarbonyl stress, which can be reduced by improving glucose metabolism through a VLCD or RYGB. These data highlight the potential to reduce reactive alpha-dicarbonyls in obese individuals with type 2 diabetes. Trial registration: ClinicalTrials.gov NCT01167959

• Advanced glycation endproducts
• alpha-Dicarbonyls
• Obesity
• Type 2 diabetes
• Weight loss interventions

• All authors: Maessen, D.E.; Hanssen, N.M.; Lips, M.A.; Scheijen, J.L.; Dijk, K.W. van; Pijl, H.; Stehouwer, C.D.; Schalkwijk, C.G.
• Date: 2016-09-01
• Journal: Diabetologia
• Volume: 59
• Issue: 9
• Pages: 2013 - 2017
• DOI: doi:10.1007/s00125-016-4009-1