Leiden University Scholarly Publications

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Corstjens, P.L.A.M.; Hooij, A. van; Fat, E.M.T.K.; Eeden, S.J.F. van den; Wilson, L.; Geluk, A. (2016)

Field-Friendly Test for Monitoring Multiple Immune Response Markers during Onset and Treatment of Exacerbated Immunity in Leprosy

Article / Letter to editor
Acute inflammatory reactions represent the major cause of irreversible neuropathy in leprosy. These tissue-destroying episodes have considerable overlap with acute immunological complications (flares) in several chronic (autoimmune) diseases that similarly warrant early detection. However, the lack of diagnostic tests impedes early diagnosis of these reactions. Here, we evaluated a user-friendly multiplex lateral flow assay for the simultaneous detection of IP-10 and anti-phenolic glycolipid I antibodies for longitudinally monitoring early onset and treatment of leprosy reactions.
All authors
Corstjens, P.L.A.M.; Hooij, A. van; Fat, E.M.T.K.; Eeden, S.J.F. van den; Wilson, L.; Geluk, A.
Date
2016-06-01
Journal
Clinical and Vaccine Immunology
Volume
23
Issue
6
Pages
515 - 519
DOI
doi:10.1128/CVI.00033-16