Leiden University Scholarly Publications

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Kruithof, B.P.T.; Duim, S.N.; Moerkamp, A.T.; Goumans, M.J. (2012)

TGFβ and BMP signaling in cardiac cushion formation: lessons from mice and chicken

Article / Letter to editor
Cardiac cushion formation is crucial for both valvular and septal development. Disruption in this process can lead to valvular and septal malformations, which constitute the largest part of congenital heart defects. One of the signaling pathways that is important for cushion formation is the TGFβ superfamily. The involvement of TGFβ and BMP signaling pathways in cardiac cushion formation has been intensively studied using chicken in vitro explant assays and in genetically modified mice. In this review, we will summarize and discuss the role of TGFβ and BMP signaling components in cardiac cushion formation.
All authors
Kruithof, B.P.T.; Duim, S.N.; Moerkamp, A.T.; Goumans, M.J.
Date
2012-07-28
Journal
Differentiation
Volume
84
Issue
1
Pages
89 - 102
DOI
doi:10.1016/j.diff.2012.04.003