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Dierckx, B.; Dieleman, G.; Tulen, J.H.M.; Treffers, P.D.A.; Utens, E.M.W.J.; Verhulst, F.C.; Tiemeier, H. (2012)

persistence of anxiety disorders and concomitant changes in cortisol

Article / Letter to editor
In a clinical sample of 116 children and adolescents we studied the relation between the course of ananxietydisorder during treatment and theconcomitantchangesincortisollevels. Assessments at baseline, after three months, and at one-year follow-up were performed with theAnxietyDisordersInterview Schedule. When we comparedcortisollevels at baseline and one-year follow-up,persistenceof theanxietydisorder was associated with both increased daytimecortisolproduction (F=3.2, p=0.04) and a trend towards a decreasedcortisolmorning rise (F=2.4, p=0.09). At one-year follow-up daytimecortisolproduction was lowest in the early remitters (109.7±29.2 h mmol/l), higher in the late remitters (121.0±40.0 h mmol/l) and highest in the non-remitters (131.1±48.9 h mmol/l). Early remitters had the highestcortisolmorning rise (1.1±1.5 h mmol/l), followed by the late remitters (0.8±1.8 h mmol/l), the non-remitters had the lowestcortisolmorning rise (0.07±1.7 h mmol/l).Persistenceof ananxietydisorder may...Show moreIn a clinical sample of 116 children and adolescents we studied the relation between the course of ananxietydisorder during treatment and theconcomitantchangesincortisollevels. Assessments at baseline, after three months, and at one-year follow-up were performed with theAnxietyDisordersInterview Schedule. When we comparedcortisollevels at baseline and one-year follow-up,persistenceof theanxietydisorder was associated with both increased daytimecortisolproduction (F=3.2, p=0.04) and a trend towards a decreasedcortisolmorning rise (F=2.4, p=0.09). At one-year follow-up daytimecortisolproduction was lowest in the early remitters (109.7±29.2 h mmol/l), higher in the late remitters (121.0±40.0 h mmol/l) and highest in the non-remitters (131.1±48.9 h mmol/l). Early remitters had the highestcortisolmorning rise (1.1±1.5 h mmol/l), followed by the late remitters (0.8±1.8 h mmol/l), the non-remitters had the lowestcortisolmorning rise (0.07±1.7 h mmol/l).Persistenceof ananxietydisorder may thus lead tochangesin HPA-axis functioning, underscoring the importance adequate treatment ofanxietydisorders.Show less
All authors
Dierckx, B.; Dieleman, G.; Tulen, J.H.M.; Treffers, P.D.A.; Utens, E.M.W.J.; Verhulst, F.C.; Tiemeier, H.
Date
2012
Journal
Journal of Anxiety Disorders
Pages
635 - 641
DOI
doi:10.1016/j.janxdis.2012.04.001