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Kouijzer, I.J.E.; Scheper, H.; Rooy, J.W.J. de; Bloem, J.L.; Janssen, M.J.R.; Hoven, L. van den; ... ; Geus-Oei, L.F. de (2018)

The diagnostic value of F-18-FDG-PET/CT and MRI in suspected vertebral osteomyelitis: a prospective study

Article / Letter to editor
Purpose The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important...Show morePurpose The aim of this study was to determine the diagnostic value of 18F–fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) and magnetic resonance imaging (MRI) in diagnosing vertebral osteomyelitis. Methods From November 2015 until December 2016, 32 patients with suspected vertebral osteomyelitis were prospectively included. All patients underwent both 18F–FDG-PET/CT and MRI within 48 h. All images were independently reevaluated by two radiologists and two nuclear medicine physicians who were blinded to each others’ image interpretation. 18F–FDG-PET/CT and MRI were compared to the clinical diagnosis according to international guidelines. Results For 18F–FDG-PET/CT, sensitivity, specificity, PPV, and NPV in diagnosing vertebral osteomyelitis were 100%, 83.3%, 90.9%, and 100%, respectively. For MRI, sensitivity, specificity, PPV, and NPV were 100%, 91.7%, 95.2%, and 100%, respectively. MRI detected more epidural/spinal abscesses. An important advantage of 18F–FDG-PET/CT is the detection of metastatic infection (16 patients, 50.0%). Conclusion 18F–FDG-PET/CT and MRI are both necessary techniques in diagnosing vertebral osteomyelitis. An important advantage of 18F–FDG-PET/CT is the visualization of metastatic infection, especially in patients with bacteremia. MRI is more sensitive in detection of small epidural abscesses.
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Vertebral osteomyelitis
F-18-Fdg-pet/ct
MRI
Abscesses
All authors
Kouijzer, I.J.E.; Scheper, H.; Rooy, J.W.J. de; Bloem, J.L.; Janssen, M.J.R.; Hoven, L. van den; Hosman, A.J.F.; Visser, L.G.; Oyen, W.J.G.; Bleeker-Rovers, C.P.; Geus-Oei, L.F. de
Date
2018-05-31
Journal
European Journal of Nuclear Medicine and Molecular Imaging
Volume
45
Issue
5
Pages
798 - 805
DOI
doi:10.1007/s00259-017-3912-0