Ketamine pharmacology revisited

Jonkman, K. (2020)

Doctoral Thesis

In the thesis I present a series of studies that focus on the use and optimization of use of low-dose ketamine in clinical practice by:
(1) reviewing the proof for its use in alleviation and prevention of acute and chronic (cancer and non-cancer) pain;
(2) testing a possible novel administration route of ketamine, i.e. inhalation;
(3) applying ketamine in a novel indication: the use of the S-enantiomer as respiratory stimulant during opioid-induced respiratory depression;
(4) studying the effect of a nitric oxide donor on ketamine (the racemic and S-ketamine variants) typical side effects that hamper it’s use in chronic pain therapy

• Ketamine
• Acute pain
• Chronic pain
• Subanesthetic dosage
• Inhalation
• Pharmacokinetic-pharmacodynamic
• NO-donor
• Side effects
• (Opioid-induced) respiratoiry depression
• Healthy volunteers

• All authors: Jonkman, K.
• Supervisor: Dahan, A.
• Co-supervisor: Velzen, M. van
• Committee: Aarts, L.P.H.J.; Sarton, E.Y.; Niesters, M.; Wee, N. van der; Hollmann, M.W.; Knibbe, C.A.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2020-01-28
• ISBN (print): 9789402818826