Basic and clinical features of cutaneous squamous cell carcinoma in organ transplant recipients

Genders, R.E. (2019)

Doctoral Thesis

The risk of cutaneous squamous cell carcinoma (cSCC) is highly increased in organ transplant recipients (OTR) and these tumours carry a major health burden for these patients. This thesis dealt with several aspects of cSCC in OTR. The chapters 2 and 3 review the role of HPV in cSCC and study HPV as a prognostic factor in the aetiology of cSCC. Subsequently, diagnostic factors were studied. In chapter 4 we intended to identify p16 as a possible histopathological marker for cSCC and in chapter 5 we studied the clinical implication of pain as a symptom to differentiate cSCC from other keratinocyte lesions. In chapter 6 we reviewed the literature on metastasis risk in immunocompetent versus OTR population. We studied in chapter 7 in our own population the risk for metastasis, and subsequently risk factors, of cSCC in OTR compared to immunocompetent patients.

• squamous cell carcinoma
• organ transplant recipient
• HPV
• p16
• pain
• metastasis

• All authors: Genders, R.E.
• Supervisor: Willemze, R.
• Co-supervisor: Bouwes, Bavink, J.N.; Quint, K.D.
• Committee: Steijlen, P.M.; Rácz, E.; Vermeer, M.H.
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden University of Medical Center [LUMC], Leiden University
• Date: 2019-11-21
• ISBN (print): 9789463805377
• Sponsorship: Financial support for the printing of this thesis was kindly provided by: DDL Diagnostic Laboratory B.V., LEO Pharma BV, Olmed, Merz Pharma Benelux B.V., La Roche-Posay, Galderma Benelux B.V., Pfizer bv, Louis Widmer Nederland, ChipSoft, BAP Medical BV, Mylan HealthCare B.V, Eucerin, miraDry.