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Laroche, C.; Annys, E.; Bender, H.; Botelho, D.; Botham, P.; Brendler-Schwaab, S.; ... ; Cronin, M.T.D. (2019)

Finding synergies for the 3Rs: Repeated Dose Toxicity testing: Report from an EPAA Partners' Forum

Article / Letter to editor
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum on repeated dose toxicity (RDT) testing to identify synergies between industrial sectors and stakeholders along with opportunities to progress these in existing research frameworks. Although RTD testing is not performed across all industrial sectors, the OECD accepted tests can provide a rich source of information and play a pivotal role for safety decisions relating to the use of chemicals. Currently there are no validated alternatives to repeated dose testing and a direct one-to-one replacement is not appropriate. However, there are many projects and initiatives at the international level which aim to implement various aspects of replacement, reduction and refinement (the 3Rs) in RDT testing. Improved definition of use, through better problem formulation, aligned to harmonisation of regulations is a key area, as is the more rapid implementation of alternatives into the...Show moreThe European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a Partners' Forum on repeated dose toxicity (RDT) testing to identify synergies between industrial sectors and stakeholders along with opportunities to progress these in existing research frameworks. Although RTD testing is not performed across all industrial sectors, the OECD accepted tests can provide a rich source of information and play a pivotal role for safety decisions relating to the use of chemicals. Currently there are no validated alternatives to repeated dose testing and a direct one-to-one replacement is not appropriate. However, there are many projects and initiatives at the international level which aim to implement various aspects of replacement, reduction and refinement (the 3Rs) in RDT testing. Improved definition of use, through better problem formulation, aligned to harmonisation of regulations is a key area, as is the more rapid implementation of alternatives into the legislative framework. Existing test designs can be optimised to reduce animal use and increase information content. Greater use of exposure-led decisions and improvements in dose selection will be beneficial. In addition, EPAA facilitates sharing of case studies demonstrating the use of Next Generation Risk Assessment applying various New Approach Methodologies to assess RDT.Show less
Repeated dose toxicity testing
Alternatives
Safety assessment
Chemical legislation
In vitro
In silico
Threshold of Toxicological Concern (TTC)
Cross-sector
Integrated Approaches for Testing and Assessment (IATA)
Weight of Evidence (WoE)
All authors
Laroche, C.; Annys, E.; Bender, H.; Botelho, D.; Botham, P.; Brendler-Schwaab, S.; Clayton, R.; Corvaro, M.; Dal Negro, G.; Delannois, F.; Dent, M.; Desaintes, C.; Desprez, B.; Dhalluin, S.; Hartmann, A.; Hubesch, B.; Hoffmann-Doerr, S.; Manou, I.; Irizar, A.; Nadzialek, S.; Müller, B.P.; Rasenberg, M.; Prieto, P.; Rowan, T.G.; Roggeband, R.; Water, B. van de; Schutte, K.; Whelan, M.; Westmoreland, C.; Zvonimir, Z.; Wilschut, A.; Cronin, M.T.D.
Date
2019-08-31
Journal
Regulatory Toxicology and Pharmacology
Volume
108
Pages
104470
DOI
doi:10.1016/j.yrtph.2019.104470