Measuring pharmacodynamics in early clinical drug studies in multiple sclerosis

Kanhai, K.M.S. (2019)

Doctoral Thesis

This thesis describes six clinical studies: two studies that investigate new compounds to treat symptoms of multiple sclerosis (MS) (chapters 2 and 3), one study that investigates a new compound to treat MS (chapter 4) and three studies about the development of new methods to determine effects of a new class of compounds to treat MS (chapters 5, 6 and 7).

• Multiple sclerosis
• Drug development
• Biomarkers
• Remyelination

• All authors: Kanhai, K.M.S.
• Supervisor: Cohen, A.F.
• Co-supervisor: Groeneveld, G.J.
• Committee: Burggraaf, J.; Lange, E.C.M. de; Killestein, J.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2019-10-10
• Sponsorship: CHDR