A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycin C.

Kleijn, L.H.J.; Vlieg, H.C.; Wood, T.M.; Sastre Toraño, J.; Janssen, B.J.C.; Martin, N.I. (2017)

Article / Letter to editor

The calcium‐dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl‐phosphate at a resolution of 1.28 Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C₅₅‐P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target.

• All authors: Kleijn, L.H.J.; Vlieg, H.C.; Wood, T.M.; Sastre Toraño, J.; Janssen, B.J.C.; Martin, N.I.
• Date: 2017-11-06
• Journal: Angewandte Chemie International Edition
• Volume: 56
• Issue: 52
• Pages: 16546 - 16549
• DOI: doi:10.1002/anie.201709240