Somatic POLE exonuclease domain mutations are early events in sporadic endometrial and colorectal carcinogenesis, determining driver mutational landscape, clonal neoantigen burden and immune response

Temko, D.; Gool, I.C. van; Rayner, E.; Glaire, M.; Makino, S.; Brown, M.; ... ; Tomlinson, I. (2018)

Article / Letter to editor

• POLE
• polymerase proofreading
• mutation
• endometrial cancer
• colorectal cancer
• precursor lesion

• All authors: Temko, D.; Gool, I.C. van; Rayner, E.; Glaire, M.; Makino, S.; Brown, M.; Chegwidden, L.; Palles, C.; Depreeuw, J.; Beggs, A.; Stathopoulou, C.; Mason, J.; Baker, A.M.; Williams, M.; Cerundolo, V.; Rei, M.; Taylor, J.C.; Schuh, A.; Ahmed, A.; Amant, F.; Lambrechts, D.; Smit, V.T.H.B.M.; Bosse, T.; Graham, T.A.; Church, D.N.; Tomlinson, I.
• Date: 2018-07-31
• Journal: Journal of Pathology
• Volume: 245
• Issue: 3
• Pages: 283 - 296
• DOI: doi:10.1002/path.5081