Comorbidities, complications and treatment of childhood obesity

Lentferink, Y.E. (2019)

Doctoral Thesis

Childhood obesity is an increasing health issue.
In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens. In children with obesity and respiratory symptoms the diagnosis of asthma was studied and in children with ADHD dosing regimens. Overtreatment as a consequence of overdiagnosis was frequently observed in children with obesity and asthma and undertreatment due to relative underdosing in the ADHD population with obesity. This highlights the necessity for accurate diagnostic processes alongside dosing regimens based on pharmacokinetic changes caused by obesity.
The focus in the second part of this thesis was on screening for complications of obesity namely insulin resistance and cardiovascular diseases. Given the high prevalence of insulin resistance and the observed changes of cardiovascular parameters, screening on cardiometabolic complications is warranted in all children with obesity.
Pharmacological treatment with metformin in addition to lifestyle intervention was studied in the last part of this thesis. Given the favorable effect on BMI in children and adults and the maintenance of weight loss and reduction in progression towards T2DM in adults, metformin can be considered in children with obesity and insulin resistance in addition to lifestyle intervention.

• Children
• Obesity
• Asthma
• ADHD
• Insulin resistance
• Metformin
• Cardiovascular diseases

• All authors: Lentferink, Y.E.
• Supervisor: Knibbe, C.A.J.
• Co-supervisor: Vorst, M.M.J. van der
• Committee: Irth, H.; Bouwstra, J.A.; Pijl, H.; Vries, M.C. de; Akker, E.L.T. van den
• Qualification: Doctor (dr.)
• Awarding Institution: Leiden Academic Centre for Drugs Research (LACDR), Faculty of Science, Leiden University
• Date: 2019-05-22
• ISBN (print): 9789463612609