Persistent URL of this record https://hdl.handle.net/1887/68231
Documents
-
- Full text
- closed access
-
- Download
- Title pages_Contents
- open access
-
- Download
- Chapter 3
- open access
- Full text at publishers site
-
- Chapter 4
- closed access
- Full text at publishers site
-
- Download
- Chapter 5
- open access
- Full text at publishers site
-
- Download
- Summary in English
- open access
-
- Download
- Summary in Dutch
- open access
-
- Download
- Propositions
- open access
In Collections
This item can be found in the following collections:
CD20 as target for immunotherapy
...Show moreMost lymphomas and leukemias are neo¬plasms of B cells. Due to the many different B cell development stages from which these neoplasms arise, the resulting diseases are quite heterogeneous, which amongst other things is manifested in different tumor growth location, proliferation potential and surface antigen repertoire. Neverthe¬less, some population characteristics are found in almost all B cell malignancies as the cell-of-origin is identical. One of these is the cell surface antigen CD20. Originally used as a marker to distinguishing B cells from other lymphocytes, it quickly became a target for immunotherapy. Immuno-therapy is a treatment that makes use of immune system components to fight cancer, in this case by the injection of a monoclonal antibody specifically targeting one protein: CD20. The addition of CD20-targeting an¬tibodies to an anti-tumor treatment allows your immune system to recognize CD20-ex¬pressing B cells (diseased and healthy), and dispose of them.
Overall, after several decades of research and therapeutic experience with antibodies targeting CD20, new functional discoveries as well as therapeutic advances are still being made, and CD20 therefore remains a highly attractive and fruitful target for the therapy of B cell malignancies as well as certain B-cell mediated autoimmune diseases.Show less
- All authors
- Engelberts, P.J.
- Supervisor
- Parren, P.W.H.I.
- Co-supervisor
- Breij, E.C.W.
- Committee
- Haas, M. de; Neefjes, J.J.C.; Hall, T. van; Spits, H.; Leusen, J.H.W.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Faculty of Medicine, Leiden Uiversity Medical Center (LUMC), Leiden University
- Date
- 2019-01-10
- ISBN (print)
- 9789402812602