Obesity and Cardiovascular disease. Results from the Netherlands Epidemiology of Obesity Study

Elffers, T.W. (2019)

Doctoral Thesis

In this thesis, the importance of visceral obesity in the relation of obesity with cardiometabolic risk factors (chapter 2) was confirmed and it was shown that in individuals free of known cardiovascular disease clustering of cardiometabolic risk factors is associated with changes in electrocardiographic parameters indicative of subclinical cardiovascular disease (chapter 3). The findings from chapter 3 also point to the importance of the prevention of these metabolic syndrome components, not only in obese, but also in non-obese individuals. Furthermore, both overall and abdominal adiposity were found to be associated with these deleterious changes in electrocardiographic parameters (chapter 4). Borderline Q-waves were associated with a negative cardiovascular risk profile and increased pulse wave velocity and intima-media thickness (chapter 5). Chapter 6 shows that several cardiovascular risk factors were associated with a wider spatial QRS-T angle, which reflects ventricular electrophysiological heterogeneity. Both carotid intima-media thickness, as measure of subclinical atherosclerosis, and pulse wave velocity, as measure of arterial stiffness, were associated with a wider spatial QRS-T angle. In chapter 7, improvement of electrocardiographic detection of left ventricular hypertrophy with conventional electrocardiographic criteria by taking into account body mass index and the spatial QRS-T angle is shown.

• Obesity
• Adipose tissue
• Electrocardiography
• Atherosclerosis
• Epidemiology

• All authors: Elffers, T.W.
• Supervisor: Jukema, J.W.; Rosendaal, F.R.
• Co-supervisor: Trompet, S.
• Committee: Cannegieter, S.C.; Mutsert, R. de; Macfarlane, P.W.; Peters, R.J.G.; Pinto-Sietsma, S.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Medicine / Leiden University Medical Center (LUMC), Leiden University
• Date: 2019-01-09
• ISBN (print): 9789463801713