The role of the tumor suppressor Lkb1 in energy homeostatis

Mans, L.A. (2018)

Doctoral Thesis

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae. We show that Lkb1 is essential for the regulation of glucose metabolism, the activation of autophagy, and hematopoiesis under conditions of metabolic stress. Furthermore, we also uncovered gene transcription profiles and hematological characteristics that are specific to lkb1 larvae, and independent of metabolic stress. Finally, we illustrate and highlight the potential of lkb1 larvae as screening platform in research related to metabolism, hematopoiesis, and tumors bearing LKB1 mutations. Overall, we have strengthened the value of lkb1 zebrafish larvae as a model to study the effects of Lkb1-inactivation on various metabolism-related processes

• Metabolism
• Lkb1
• Metabolic adaptation
• Zebrafish
• Synthetic lethality screen
• Cancer metabolism
• Autophagy
• Hematopoiesis

• All authors: Mans, L.A.
• Supervisor: Meijer, A.H.
• Co-supervisor: Haramis, A-P.G.
• Committee: Spaink, H.P.; Richardson, M.K.; Hertog, J. den; Guigas, B.; Giles, R.
• Qualification: Doctor (dr.)
• Awarding Institution: Institute of Biology Leiden (IBL), Faculty of Science, Leiden University
• Date: 2018-12-06
• ISBN (print): 9789082361940
• Sponsorship: KWF