Leiden University Scholarly Publications

Persistent URL of this record https://hdl.handle.net/1887/67425

In Collections

This item can be found in the following collections:

Yang, J. (2018)

Molecular and genetic markers for the prediction of kidney transplant outcome

Doctoral Thesis
Kidney transplantation is the preferred treatment of patients with end stage renal disease, as it provides longer patient survival and better quality of life compared to dialysis. Prediction of DGF, response to steroid resistant rejection and long-term graft outcome remain difficult when using merely clinical parameters. Numerous studies have reported on the predictive value of molecular markers for AR and worse graft outcome. However, the heterogeneity of AR and the variation among transplant centers leads to controversial results and preclude a more general clinical application. In the first part of this thesis, we aimed to investigate the molecular markers of steroid resistance and long-term graft survival on the basis of acute rejection biopsies. In the second part, we focused on genetic variants associated with acute rejection in kidney transplantation. In the final part we described the possible immune regulatory effect of S100 calcium binding...Show moreKidney transplantation is the preferred treatment of patients with end stage renal disease, as it provides longer patient survival and better quality of life compared to dialysis. Prediction of DGF, response to steroid resistant rejection and long-term graft outcome remain difficult when using merely clinical parameters. Numerous studies have reported on the predictive value of molecular markers for AR and worse graft outcome. However, the heterogeneity of AR and the variation among transplant centers leads to controversial results and preclude a more general clinical application. In the first part of this thesis, we aimed to investigate the molecular markers of steroid resistance and long-term graft survival on the basis of acute rejection biopsies. In the second part, we focused on genetic variants associated with acute rejection in kidney transplantation. In the final part we described the possible immune regulatory effect of S100 calcium binding proteins. Show less
Kidney transplant outcome
Acute rejection
Innate immune related genes
Endothelial epithelial related
Genome wide association study
Missense SNPs mismatching
Calcium binding proteins
Immune regulation
All authors
Yang, J.
Supervisor
Claas, F.H.J.
Co-supervisor
Eikmans, M.
Committee
Koning, F.; Reinders, M.E.J.; Florquin, S.; Otten, H.G.
Qualification
Doctor (dr.)
Awarding Institution
Faculty of Medicine, Leiden Uiversity Medical Center (LUMC), Leiden University
Date
2018-12-19
ISBN (print)
9789402812442

Funding

Sponsorship
National Reference Center for Histocompatibility Testing, Nederlandse Transplantatie Vereniging