SDHD-related head and neck paragangliomas & their natural course

Heesterman, B.L. (2018)

Doctoral Thesis

SDHD-related head and neck paragangliomas are, hereditary and generally benign, neuroendocrine tumors that arise from paraganglionic tissue associated with the parasympathetic nervous system. The primary aim of this thesis was to gain more insight in the natural course of SDHD-related head and neck paragangliomas and ultimately improve surveillance and treatment strategies, as well as counseling of both patients and their family members. The risk of occult and metachronous paragangliomas, tumor growth, clinical progression and survival of SDHD germline mutation carriers were addressed.

• SDHD mutation
• Paragangliomas
• Carotid body tumors
• Vagal body tumors
• Tumor volume
• Growth
• Prediction
• Mathematical models
• Clinical progression
• Mortality

• All authors: Heesterman, B.L.
• Supervisor: Benthem, P.P.G. van
• Co-supervisor: Jansen, J.C.; Verbist, B.M.
• Committee: Frijns, J.H.M.; Kremer, B.; Laan, B.F.A.M. van der; Hes, F.J.; Kleij-Corssmit, E.P.M. van der
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden Uiversity Medical Center (LUMC), Leiden University
• Date: 2018-09-13