Advanced imaging and spectroscopy techniques for body magnetic resonance

Heer, P. de (2018)

Doctoral Thesis

The aim of this thesis was to develop advanced body MR techniques that can contribute to
the knowledge of the metabolic syndrome (MetS). Such techniques are important since
the incidence of the metabolic syndrome is reaching pandemic proportions.
We looked In the first part of this thesis, consisting of chapters 2, 3 and 4, new techniques for body
MR were developed. Firstly high dielectric passive shimming was developed and applied on liver imaging to increase image quality. Furthermore, the required power was reduced by applying the passive shimming method. Secondly MR spectroscopy was optimized to reliably measure lipid levels in the heart and kidney. By looking at the various parameters and optimizing them individually very high measurement reproducibility was reached. Even though MR spectroscopy is a great tool for studying MetS the complexity of the technique hampers broad application therefore, extra emphasis was placed on the ease of use of the developed protocol. In the second part of the thesis the previously mentioned methods were applied in a more clinical setting.

• Body imaging
• High dielect materials
• MR spectroscopie
• Metabolic syndrome
• DM2

• All authors: Heer, P. de
• Supervisor: Webb, A.G.; Lamb, H.J.
• Co-supervisor: Vries, A.P.J. de
• Committee: Lelieveldt, B.P.F.; Leiner, T.; Versluis, M.J.; Kan, H.E.
• Qualification: Doctor (dr.)
• Awarding Institution: Medicine / Leiden University Medical Center (LUMC), Leiden University
• Date: 2018-05-23
• ISBN (print): 9789490858568
• Sponsorship: Nierstichting; Hartstichting