Prognostics of outcome of total knee replacement: on patient selection and intraoperative issues

Verra, W.C. (2018)

Doctoral Thesis

In this thesis first we show that patients after total hip replacement are more satisfied than patients after total knee replacement (TKR). The indication to perform TKR is important. We studied the reason for orthopedic surgeons to recommend TKR. It seemed that the radiological osteoarthritis and age were most important. We compared Dutch orthopedic surgeons with those from other countries. Also we studied how well the oldest old patients (85+) perform with or without total joint replacement. In part 2 of the thesis more technical issues are addressed. A RCT studying the effect of fibrin sealant on postoperative knee function. No beneficial effect could be shown for the fibrin sealant. A Cochrane review and meta-analysis studying whether to sacrifice or retain the posterior cruciate ligament in TKR. It seemed there was no clinical difference between the two. Finally a RCT studying two different kinds of warming blankets applied during total joint replacement showed no evident difference between the two. 

• Total Knee Replacement
• Indication
• Orthopedics
• Fibrin Sealant
• Systematic Review
• Posterior cruciate ligament
• Meta-analysis
• Warming blankets
• Randomized controlled trials
• Oldest old

• All authors: Verra, W.C.
• Supervisor: Nelissen, R.G.H.H.
• Co-supervisor: Hilten, J.A. van
• Committee: Kloppenburg, G.; Bom, J.G. van der; Verhaar, J.A.N.; Perka, C.
• Qualification: Doctor (dr.)
• Awarding Institution: Orthopedie, Medicine / Leiden University Medical Center (LUMC), Leiden University
• Date: 2018-07-04
• ISBN (print): 9789463323468
• Sponsorship: Nederlandse Orthopaedische Vereniging; Ossur Europe; Hanssen Footcare; Mathys Orthopaedics BV; Anna fond ; OREF; Bauerfeind Benelux BV; Chipsoft BV; Implantcast Benelux BV; KBC Haaglanden; ETB-BISLIFE; van Dinter Orthopedie Den Haag; van Gils Footcare BV