Multivariate pharmacokinetic/pharmacodynamic (PKPD) analysis with metabolomics shows multiple effects of remoxipride in rats

Brink, W.J. van den; Elassaiss, J.; Gonzalez Amoros, B.; Harms, A.C.; Graaf, P.H. van der; Hankemeier, T.; Lange, E.C.M. de (2017)

Article / Letter to editor

• Systems pharmacology
• PK/PD modeling
• Pharmacometabolomics
• Biomarkers
• CNS drugs
• D2R antagonists

• All authors: Brink, W.J. van den; Elassaiss, J.; Gonzalez Amoros, B.; Harms, A.C.; Graaf, P.H. van der; Hankemeier, T.; Lange, E.C.M. de
• Date: 2017-11-15
• Journal: European Journal of Pharmaceutical Sciences
• Volume: 109
• Pages: 431 - 440
• DOI: doi:10.1016/j.ejps.2017.08.031
• Link: https://www.sciencedirect.com/science/article/pii/S0928098717304888?via=...