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Development and application of glyco-bioinformatics packages for targeted quantitation
This dissertation describes the development of glyco-bioinformatics tools that facilitate the high-throughput data processing of glycomics and glycoproteomics experiments, specifically for both MALDI-TOF-MS (Chapter 2) and LC-ESI-MS (Chapter 3). The developed methods also provide various quality control parameters that assist the researcher in curating both the measured spectra and quantified analytes, thereby providing high-quality data in a high-throughput manner.
The tools that were developed within this thesis have been used to identify the influence of glycosylation on trypsin efficacy of Immunoglobulin G (Chapter 3) and two biological cohorts. Specifically, to investigate the serum N-glycosylation during and after pregnancy (Chapter 5) and to identify the differences in the N-glycosylation between maternal and fetal serum and IgG (Chapter 6).
- All authors
- Jansen, B.C.
- Editor(s)
- Jansen B.C.
- Supervisor
- Wuhrer, M.; Deelder, A.M.
- Co-supervisor
- Falck, D.
- Committee
- Lisacek, F.; Lankester, A.C.; Mons, B.; Irth, H.; Houwing-Duistermaat, J.J.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Medicine , Leiden University
- Date
- 2017-10-10
- ISBN (print)
- 9789462957237