T cell metabolism in metabolic disease-associated autoimmunity

Amersfoort, J.; Kuiper, J.; Amersfoort J, Kuiper J.

doi:doi:10.1016/j.imbio.2017.03.001

Persistent URL of this record https://hdl.handle.net/1887/55509

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Leiden Academic Centre for Drug Research (LACDR)

Amersfoort, J.; Kuiper, J. (2017)

T cell metabolism in metabolic disease-associated autoimmunity

Article / Letter to editor

This review discusses the relevant metabolic pathways and their regulators which show potential for T cell metabolism-based immunotherapy in diseases hallmarked by both metabolic disease and autoimmunity. Multiple therapeutic approaches using existing pharmaceuticals are possible from a rationale in which T...Show moreThis review discusses the relevant metabolic pathways and their regulators which show potential for T cell metabolism-based immunotherapy in diseases hallmarked by both metabolic disease and autoimmunity. Multiple therapeutic approaches using existing pharmaceuticals are possible from a rationale in which T cell metabolism forms the hub in dampening the T cell component of autoimmunity in metabolic diseases. Future research into the effects of a metabolically aberrant micro-environment on T cell metabolism and its potential as a therapeutic target for immunomodulation could lead to novel treatment strategies for metabolic disease-associated autoimmunity.Show less