Unravelling narcolepsy : from pathophysiology to measuring treatment effects

Heide, A. van der (2017)

Doctoral Thesis

Narcolepsy is a disorder of the regulation of sleep and wakefulness, with as its major features excessive daytime sleepiness (EDS), cataplexy, hypnagogic hallucinations, sleep paralysis and disturbed nocturnal sleep. The first part of this thesis concernes an overview of the pathophysiology, symptoms and treatment of narcolepsy type 1. The second part elaborates some pathophysiological aspects, focussing on the autoimmune hypothesis of narcolepsy. The third part focuses on alterations of temperature regulation and on measuring treatment effects of symptomatic treatment on sustained attention, i.e. vigilance.

 

• Narcolepsy
• Autoimmune
• Cataplexy
• SART
• Vigilance
• Symptoms
• Treatment

• All authors: Heide, A. van der
• Supervisor: Dijk, J.G. van
• Co-supervisor: Lammers, G.J.
• Committee: Claas, F.H.J.; Overeem, S.; Hintzen, R.Q.; Jager, M.J.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2017-05-24
• ISBN (print): 9789490791551