The contribution of metabolic and adipose tissue inflammation to non-alcoholic fatty liver disease

Mulder, P.C.A. (2017)

Doctoral Thesis

Non-alcoholic fatty liver disease (NAFLD) has rapidly become the most common cause of chronic liver disease, and its worldwide prevalence continues to increase in parallel of the obesity epidemic. NAFLD comprises a wide spectrum of liver damage ranging fat accumulation (steatosis) to steatosis with inflammation (non-alcoholic steatohepatitis, NASH), which can further progress to fibrosis. In particular patients with NASH have increased risk to develop other metabolic complications, such as cardiovascular disease.
NAFLD is a complex disease, in which the origin and molecular mechanisms controlling the progression of simple steatosis to NASH remain poorly understood. Nevertheless, it is thought that inflammation is a critical component of NAFLD progression. This inflammation may be triggered by metabolic surplus (excess of energy or nutrients) and is also referred to as “metabolic inflammation”. White adipose tissue (WAT) is assumed to be largely involved in the development of metabolic inflammation. The studies described in this thesis contributed to the understanding of the role of WAT in the development of NAFLD and provide insight into the molecular processes that cause metabolic inflammation.

• NAFLD/NASH
• Obesity
• Adipose tissue
• Adipokines
• Inflammation
• Insulin resistance
• Dyslipidemia
• Atherosclerosis

• All authors: Mulder, P.C.A.
• Supervisor: Bockel, J.H. van
• Co-supervisor: Kleemann, R.
• Committee: Havekes, L.M.; Smulders, Y.M.; Verheij, J.
• Qualification: Doctor (dr.)
• Awarding Institution: Department of Vascular Surgery, Medicine, Leiden University
• Date: 2017-02-16
• ISBN (print): 9789462334861
• Sponsorship: Department of Metabolic Health Research, TNO