Regulation of arteriogenesis: Mechanistic studies and options for therapeutic intervention

Bastiaansen, A.J.N.M. (2017)

Doctoral Thesis

The studies included in this thesis demonstrated a preclinical murine
model to study neovascularization in vivo and subsequently a number of potential targets to stimulate therapeutic neovascularization. This thesis contributes to a better
insight into mechanisms underlying post-ischemic neovascularization and offers new therapeutic perspective to current treatment strategies for patients with critical limb
ischemia. Whether stagnated blood flow recovery after an occlusive event is due to restricted pre-existing collateral bed or due to decreased collateral remodeling, we are
now closer to a tailor made treatment available for each patient with peripheral arterial disease.

• Neovascularization
• Arteriogenesis
• Angiogenesis
• Peripheral arterial disease
• Critical limb ischemia

• All authors: Bastiaansen, A.J.N.M.
• Supervisor: Quax, P.H.A.
• Co-supervisor: Nossent, A.Y.
• Committee: Goumans, M.J.T.H.; Zonneveld, A.J. van; Jukema, J.W.; Hoefer, I.E.; Kuiper, J.; Knippenberg, B.
• Qualification: Doctor (dr.)
• Awarding Institution: Medicine, Leiden University
• Date: 2017-02-09
• ISBN (print): 9789090300665