Biomarkers in early phase development of central nervous system drugs: a conceptual framework

Post, J. van der (2006)

Doctoral Thesis

The main objective of this thesis is to provide a conceptual framework for the use of Central Nervous System (CNS) biomarkers in early phase clinical drug development. In the Introduction the current use of biomarkers in early CNS drug development is discussed. A conceptual framework for the classification of biomarkers is suggested, based on general questions that these markers should provide information on. The body of this thesis (Chapters 1-7) exemplifies the use of these markers within this conceptual framework. In the Conclusions and Discussion a critical evaluation of the presented conceptual biomarker framework is give and directions for future biomarker research are offered.

• Biomarkers
• CNS
• Drug development
• Pharmacology

• All authors: Post, J. van der
• Supervisor: Cohen, A.F.; Gerven, J.M.A. van
• Qualification: Doctor (dr.)
• Awarding Institution: Centre for Human Drug Research, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2006-09-26
• Court: LEI Universiteit Leiden
• Sponsorship: Centre for Human Drug Research