Coeliac disease : prevention and improvement of care

Vriezinga, S.L. (2016)

Doctoral Thesis

Coeliac disease (CD) is an immune-mediated systemic disorder elicited by gluten in genetically susceptible individuals. The aim of this thesis was to investigate the influence of infant feeding on prevention and development of childhood CD (part 1) and to explore new strategies for improvement of care for CD children and young adults (part 2). In part 1, the European multi-centre randomized double-blind placebo-controlled dietary intervention-study in high-risk children (www.preventcd.com) is presented. Based on retrospective studies suggesting a ‘window of opportunity’ for primary prevention of CD, parents were advised to introduce gluten between 4–6 months of age. Our results show that this did not reduce the risk of CD by 3 years of age and contributed to a new European guideline stating that gluten may be introduced between age 4-12 months. Part 2 shows that physicians overestimate the CD specific health-related quality-of-life (HRQOL) of CD patients, supporting implementation of self-reported CD-specific HRQOL measurements during follow-up. Compared to traditional hospital visits for treated CD, E-health was cost-saving, satisfactory, and significantly improved the CD-specific HRQOL. As E-health requires a point-of-care test suitable for follow-up of treated CD, three different tests were compared with conventional ELISA and one was found to be suitable.

• Coeliac disease
• Children
• Young adults
• Prevention
• E-health
• Point-of-care test
• HRQoL

• All authors: Vriezinga, S.L.
• Supervisor: Rings, E.H.H.M
• Co-supervisor: Mearin, M.L.
• Committee: Escher, J.C.; Koning, F.; Lankester, A.C.; Wijmenga, C.
• Qualification: Doctor (dr.)
• Awarding Institution: Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2016-12-07
• ISBN (print): 9789462994560
• Sponsorship: Maag Lever Darm Stichting