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- Part I Modulation of B cell responses
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Immune regulation by CD49b+ CD4+ T cells & modulation of B cell responses
In this thesis, we have addressed aspects of two main arms of the adaptive immune system; the B cell and antibody arm and the T cell arm. This led to a division in the presentation of the results described in this thesis into two sections. In the first section, we present the results regarding the characterization of ACPA responses, B cells and ACPA secreting plasmablasts/-cells in RA as well as autoantibody responses and their regulation by an effective anti-rheumatic drug, abatacept, in the arthritis mouse model; Collagen Induced Arthritis (CIA). The second section is compiled of results obtained from studies examining the regulatory and other aspects of CD49b+CD4+ T cells on proinflammatory responses involved in the pathogenesis of arthritis.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the...
In this thesis, we have addressed aspects of two main arms of the adaptive immune system; the B cell and antibody arm and the T cell arm. This led to a division in the presentation of the results described in this thesis into two sections. In the first section, we present the results regarding the characterization of ACPA responses, B cells and ACPA secreting plasmablasts/-cells in RA as well as autoantibody responses and their regulation by an effective anti-rheumatic drug, abatacept, in the arthritis mouse model; Collagen Induced Arthritis (CIA). The second section is compiled of results obtained from studies examining the regulatory and other aspects of CD49b+CD4+ T cells on proinflammatory responses involved in the pathogenesis of arthritis.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by inflammation of the synovial membrane of the joints, culminating in destruction of cartilage and deformity of the joints if remains untreated. Infiltration of inflammatory immune cells such as B cells and T cells into the inflamed joints is a characteristic feature of RA. These immune cells are in continuous interaction with each other and create a viscous circle that sustains persistent synovitis and damage to articular cartilage.
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- All authors
- El-Bannoudi, Hanane
- Supervisor
- Toes, R.E.M.; Huizinga, T.W.J.
- Committee
- Ossendorp, F.A.; Kooten, C. van; Quax, P.H.A.; Kuiper, J.; Duivenvoorde, L.M. van; Ioan-Fascinay, A.
- Qualification
- Doctor (dr.)
- Awarding Institution
- Medicine , Leiden University
- Date
- 2016-11-29
- ISBN (print)
- 9789462994652
Funding
- Sponsorship
- The research leading to the results presented in this thesis has received funding from The European Community’s Seventh Framework Programme FP7, Centre for Medical Systems Biology (CMSB), Dutch Arthritis Foundation, programme Masterswitch, the Netherlands Organisation for Scientific Research (a Vici grant) and the Innovative Medicines Initiative-funded project BeTheCure