Advancing surgical guidance: from (hybrid) molecule to man and beyond

Berg, N.S. van den (2016)

Doctoral Thesis

 

The work described in this thesis shows how intraoperative lesion identification can be improved via the introduction of (hybrid) tracers and optimised (hybrid) imaging modalities capable of detecting this tracers. In part one, the reader is introduced to the concept of fluorescence image-guided surgery and the evolution thereof. Furthermore the hybrid approach for image-guided surgical guidance is presented. Part two describes the clinical evaluation of the hybrid approach using the hybrid tracer indocyanine green-technetium 99m-nanocolloid. To further refine the hybrid approach for surgical guidance, part three of this thesis describes the development and evaluation of different types of (hybrid) imaging modalities.

 

• Sentinel node
• SPECT/CT
• Fluorescence
• Imaging
• Surgery
• Hybrid tracer

• All authors: Berg, N.S. van den
• Supervisor: Bloem, J.L.
• Co-supervisor: Leeuwen, F.W.B. van; Valdés Olmos, R.A.
• Committee: Tanke, H.J.; Balm, A.J.M.; Jong, M.A. de; Poel, H.G. van der
• Qualification: Doctor (dr.)
• Awarding Institution: Medicine, Leiden University
• Date: 2016-11-10
• ISBN (print): 9789463320924