Growth, endocrine function and quality of life after haematopoietic stem cell transplantation

Bakker, B. (2006)

Doctoral Thesis

This thesis contains the results of several studies on the long-term consequences of the myeloablative conditioning for haematopoietic stem cell transplantation (SCT) during infancy and childhood, with the emphasis on late effects on endocrine functions. After a general introduction, effects of total-body irradiation (TBI) on pituitary and thyroid glands in rhesus monkeys and effects of irradiation on growth plates in growing rats are discussed. After these experimental animal data, effects of different conditioning regimens for SCT in children on growth, pubertal development, thyroid function and quality of life are discussed in subsequent chapters, and results of growth hormone therapy in these patients are presented. All study results presented in the thesis and relevant data from the literature are integrated into a general discussion at the end of the thesis.

• Haematopoietic stem cell transplantation
• Quality of life
• Gonadal function
• Total-body irradiation
• Longitudinal growth growth hormone secretion
• Growth hormone secretion
• Thyroid function
• Pubertal development
• Fertility

• All authors: Bakker, B.
• Supervisor: Wit, J.M.; Vossen, J.M.J.J.
• Co-supervisor: Oostdijk, W.
• Qualification: Doctor (dr.)
• Awarding Institution: Department of Paediatrics, Faculty of Medicine, Leiden University Medical Center (LUMC), Leiden University
• Date: 2006-04-27
• Publisher: Wageningen: Ponsen & Looijen b.v.
• ISBN (print): 9789090203362
• Court: LEI Universiteit Leiden
• Sponsorship: The Research presented in this thesis was financially supported by the Netherlands’ Orginazation for Scientific Research (NWO / ZonMw). For publication of this thesis, financial support from Ferring Geneesmiddelen B.V., Ipsen Farmaceutica B.V., Novo Nordisk Farma B.V., Pfizer B.V., Eli Lilly Nederland B.V. and ZonMw is gratefully acknowledged.