Leiden University Scholarly Publications

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Kraan, H.; Stel, W. van der; Kersten, G.F.A.; Amorij, J.P. (2016)

Alternative administration routes and delivery technologies for polio vaccines.

Article / Letter to editor
Global polio eradication is closer than ever. Replacement of the live attenuated oral poliovirus vaccine (OPV) by inactivated poliovirus vaccine (IPV) is recommended to achieve complete eradication. Limited global production capacity and relatively high IPV costs compared to OPV spur the need for improved polio vaccines. The target product profile of these vaccines includes not only dose sparing but also high stability, which is important for stockpiling, and easy application important for (emergency) vaccination campaigns. In this review, the current status of alternative polio vaccine delivery strategies is given. Furthermore, we discuss the feasibility of these strategies by highlighting challenges, hurdles to overcome, and formulation issues relevant for optimal vaccine delivery.
All authors
Kraan, H.; Stel, W. van der; Kersten, G.F.A.; Amorij, J.P.
Date
2016
Journal
Expert review of vaccines
Volume
15
Issue
8
Pages
1029 - 1040